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Yao, Fengxian; Xu, Chuan-Yuan; Yu, Sha; Li, J.X.; Gao, Yujie; Li, X.H.; Zhang, Qifa

doi:10.1023/a:1003165116059

Cited by 106 publications

(25 citation statements)

References 13 publications

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“…Moreover, C1P-stimulated MCP-1 release was completely abolished by PTX, an action that is compatible with the existence of a specific G i protein-coupled receptor for C1P (23). The implication of Akt, ERK1/2, and p38 in this C1P action is consistent with previous work by other groups showing that MCP-1 upregulated these kinases in different cell types, including rat aortic smooth muscle cells (55), proximal tubular cells (51), 3T3-L1 preadipocytes (56), vascular smooth muscle cells (12), and monocytes (33). Nonetheless, although MCP-1 release has been associated with activation of p38 in many instances (8,33,56; and our unpublished observations), other studies have indicated that this kinase is not involved in this process (31,35), and therefore the role of p38 in stimulation of MCP-1 secretion remains controversial.…”

Section: Discussionsupporting

confidence: 89%

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Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration

Arana

Ordoñez

Ouro

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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(C1P) is implicated in inflammatory responses and was recently shown to promote cell migration. However, the mechanisms involved in these actions are poorly described. Using J774A.1 macrophages, we have now discovered a new biological activity of C1P: stimulation of monocyte chemoattractant protein-1 (MCP-1) release. This novel effect of C1P was pertussis toxin (PTX) sensitive, suggesting the intervention of Gi protein-coupled receptors. Treatment of the macrophages with C1P caused activation of the phosphatidylinositol 3-kinase (PI3K)/Akt, mitogen-activated protein kinase kinase (MEK)/extracellularly regulated kinases (ERK), and p38 pathways. Inhibition of these kinases using selective inhibitors or specific siRNA blocked the stimulation of MCP-1 release by C1P. C1P stimulated nuclear factor-B activity, and blockade of this transcription factor also resulted in complete inhibition of MCP-1 release. Also, C1P stimulated MCP-1 release and cell migration in human THP-1 monocytes and 3T3-L1 preadipocytes. A key observation was that sequestration of MCP-1 with a neutralizing antibody or treatment with MCP-1 siRNA abolished C1P-stimulated cell migration. Also, inhibition of the pathways involved in C1P-stimulated MCP-1 release completely blocked the stimulation of cell migration by C1P. It can be concluded that C1P promotes MCP-1 release in different cell types and that this chemokine is a major mediator of C1P-stimulated cell migration. The PI3K/Akt, MEK/ ERK, and p38 pathways are important downstream effectors in this action.ceramide 1-phosphate; monocyte chemoattractant protein-1 release; macrophage migration; sphingosine 1-phosphate REGULATION OF CELL MIGRATION is a complex process involving hundreds of molecules. It is necessary for tissue homeostasis and is crucial for regulation of vital biological processes including embryogenesis, organogenesis, or regeneration (reviewed in Refs. 38, 48). Also, cell migration is fundamental to inflammatory responses (1, 49), but inadequate migratory signals may induce the migration of the wrong cell type to the wrong place, which may have severe effects in the organism. Some examples include autoimmune syndromes, angiogenesis, or the process of metastasis. Although cell migration is a subject of intense investigation, the mechanisms involved in controlling cell movements are incompletely understood. In this connection, growing evidence suggests that some sphingolipids are key metabolites for controlling chemotaxis (52). Our group recently reported that ceramide 1-phosphate (C1P), a sphingolipid metabolite that is present in serum or plasma (25), and which we found to regulate cell growth and survival (15,17,18,20,22), is a chemoattractant molecule for macrophages (23). This finding is particularly relevant when considering that macrophages play critical roles in chronic and acute inflammation and that these cells facilitate cancer cell migration (21, 46). In addition, Barth et al. (4) recently showed that ceramide kinase, the enzyme responsible for the phosphorylation of ce...

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Section: Discussionsupporting

confidence: 89%

“…E 2 (unpublished observations). MCP-1 has also been associated with stimulation of cell proliferation in both healthy and malignant cells (7,55), and although it did not affect the growth of bladder cancer cells, it mediated migration and invasion of those cells (9) and facilitated metastasis to bone, lung, and prostate (6,36,47,57).…”

Section: Discussionmentioning

confidence: 99%

Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration

Arana

Ordoñez

Ouro

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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“…Rf3 and Rf4 (Shah et al 2012). The effect of Rf4 (located on chromosome 10) was greater than that of Rf3 (chromosome 1) on its ability for restoring pollen fertility of WA-CMS (Yao et al 1997). These two gene mechanisms are similar to those reported by Nematzadeh and Kiani (2010).…”

Section: Introductionsupporting

confidence: 75%

Diversity and Capability Analyses of Fertility Restorer Genes of Cytoplasmic Male Sterile Rice Lines Using SSR

Widyastuti

Yunus

Purwoko

et al. 2018

Indones. J. Agric. Sci.

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Development of hybrid rice depends on the effectivity of cytoplasmic male sterility (CMS) and restorer (R) lines. The molecular genetic approach is expected to help the breeder in identification of suitable parental lines to hybrid rice improvement. The study aimed to assess genetic relationship among three types of CMS systems (wild abbortive/WA Kalinga and Gambiaca) as female parents and to identify diversity of genes controlling fertility restoration in rice. The study used nine F 1 hybrids and F 2 populations obtained from the hybridization of three different CMS lines (IR58025A-WA, IR80156A-Kalinga and IR80154A-Gambiaca) with three restorer lines (PK90, PK12 and BP11). Fifteen SSR markers were used to select genomic regions of chromosome 1 and 10 on which Rf3 and Rf4 genes located in the hybrids. The results showed that fertility restoration in CMS-WA and CMS-Gambiaca was governed by two independent and dominant genes (Rf3 and Rf4), while in CMS-Kalinga the fertility restoration was controlled by one single dominant gene. Biological processes occurred in the fertility restoration of the hybrids were the same based on the pollen and spikelet fertilities of F 1 hybrids derived from three CMS and R lines, i.e. 76.1-78.3% and 69.1-76.6%, respectively. A restorer line PK12 had a higher capability in fertility restoration than PK90 and BP11. The SSR primers RM490 and RM258 were capable of identifying the Rf3 and Rf4 genes controlled fertility restoration in CMS-WA. The study supports the use of male sterile WA in rice hybridization.

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“…We also found a sequence variant of orf352 in an RT102 CMS line derived from O. rufipogon (Okazaki et al 2013). However, the Rf genes in nuclear genome have not yet been cloned, although two major Rf genes, Rf3 and Rf4, have been mapped on the chromosomes 1 and 10, respectively (Lu et al [1997]; Yao et al [1997]; Tan et al [2008]; Jing et al [2001]; Ahmadikhah and Karlov [2006]; Ngangkham et al [2010]; Suresh et al [2012]). In this study, we report the cloning of Rf4 .…”

Section: Resultsmentioning

confidence: 99%

A fertility restorer gene, Rf4, widely used for hybrid rice breeding encodes a pentatricopeptide repeat protein

Kazama

Toriyama

2014

Rice

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BackgroundUncontrolled expression of a certain mitochondrial gene often causes cytoplasmic male sterility (CMS) in plants. This phenotype is prevented by the presence of a fertility restorer (Rf) gene in the nuclear genome. Such CMS/Rf systems have been successfully used for breedings of F1 hybrid cultivars. In rice, approximately 99% of F1 hybrid cultivars have been developed using a wild abortive type of CMS (WA-CMS) and its Rf genes. Recently, a newly identified mitochondrial gene, orf352, was reported as a WA-CMS-causing gene.FindingsWe cloned and functionally characterized Rf4, a major Rf gene for WA-CMS. We revealed that Rf4 encoded a pentatricopeptide repeat-containing protein and reduced the orf352-containing transcripts, thereby restoring pollen fertility.ConclusionsThrough a map-based cloning, we have independently identified an allele of a recently reported Rf4 gene and demonstrated that the fertility restoration is controlled sporophytically.Electronic supplementary materialThe online version of this article (doi:10.1186/s12284-014-0028-z) contains supplementary material, which is available to authorized users.

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Cited by 106 publications

References 13 publications

Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration

Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration

Diversity and Capability Analyses of Fertility Restorer Genes of Cytoplasmic Male Sterile Rice Lines Using SSR

A fertility restorer gene, Rf4, widely used for hybrid rice breeding encodes a pentatricopeptide repeat protein

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