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Abstract

Elephantopus scaber contains secondary metabolites, such as triterpenoids, sesquiterpene lactones, elephantopin, epifriedelinol, lupeol, stiqmasterol, lupeolacetate, deoxyelephantopin, and isodeoxyelephantopin. The plant can be used for medicinal purposes to treat cancer, diabetes, leukemia, viral and bacterial infections, bronchitis, and hepatitis. Therefore, this research aims to isolate and identify the bio-active compounds in Elephantopus scaber leaf extract and to analyze the effectiveness of binding the constituents through molecular docking against NF-kB. The method used included two stages. The first stage was extraction, fractionation, isolation, and identification, while the second was the in silico test, including the sample preparation, molecular docking, and visualization. The results showed that 10 bioactive compounds had the potential as anti-cancer compounds. Based on the binding affinity of the molecular docking, the compounds with the lowest values were b-amyrin (-8.0 kcal/mal), a-amyrin (-6.9 kcal/mol), and Cycloartane-3.beta 25-diol (-6.9 kcal/mol). Furthermore, the three compounds have potential as anti-cancer agents.

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“…Anemia is one of the most common hematological disorders found in cancer patients in almost >40% of cases. It can also serve as an adverse prognostic factor [5] and affect patients with hematological malignancies, such as patients with Multiple Myeloma, Non-Hodgkin Lymphoma (NHL), Hodgkin Lymphoma, Chronic Lymphocytic Leukemia (CLL), and Myelodysplastic syndrome (MDS) [6]. Separating leukocytes with a special filter produces Packed Red Cell (PRC) products with a leukocyte count of <5×10 6 per unit [7], referred to as leukodepleted PRC.…”