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Abstract

ABSTRACT:The leaves of Corchorus trilocularis possesses several bioactivities and is used in traditional medicinal systems. However, its antidiabetic activity has not been scientifically investigated so far. The present study was carried out to evaluate the anti-diabetic activity of chloroform extract extract of Corchorus trilocularis (family: Tiliaceae) leaves in Streptozotocin induced diabetic rats. Chloroform extract showed presence of saponins, phytosterols, flavonoids, phenols, steroids and terpenoids. From the toxicity study it was observed that chloroform extract of Corchorus trilocularis (CECT) was nontoxic up to the dose of 2000 mg/kg body weight. In this study, animals received continuous oral administration of CECT for a period of 21 days at the doses of 200 mg/kg and 400 mg/kg body weight. The effect of CECT was compared with oral dose of 5mg/kg Glibenclamide. The results showed that the CECT significantly lowered the blood sugar level of hyperglycemic rats in a dose dependent manner. CECT reduced glycosylated hemoglobin, lactate dehydrogenase and creatinine kinase levels in streptozotocin treated animals. The extract also ameliorated oxidative stress Parameters -TBARS, catalase and superoxide dismutase activity and glutathione content. In conclusion, the chloroform extract of Corchorus trilocularis leaves showed a significant anti-diabetic activity in streptozotocin induced diabetic rats possibly through increased secretion of insulin and the effect may be attributed to the presence of flavonoids and phenolic compounds present in extract.