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Hirano, H; Omichi, M; Ohishi, Hifumi; Ishikawa, Koichi

doi:10.1539/joh1959.25.503

Cited by 1 publication

(1 citation statement)

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“…The enzyme catalyzes the reaction of 2 δ-aminolevulinic acid to porphobilinogen + 2 H 2 O and is involved in the heme biosynthetic pathway [25]. Lead has been demonstrated to inhibit the activity of ALAD; the simple natural process of red blood cell aging has also been shown to have an effect [26][27][28]. As a factor of heme synthesis, the inhibition of ALAD or its mutation may lead to anemia [29,30].…”

Section: Introductionmentioning

confidence: 99%

Pre-Ride Biomarkers and Endurance Horse Welfare: Analyzing the Impact of the Elimination of Superoxide Dismutase, δ-Aminolevulinic-Dehydratase, Thiobarbituric Acid Reactive Substances, Iron, and Serum Amyloid A Levels in Elite 160 km Endurance Rides

Bollinger

Bartel

Weber

et al. 2023

Animals

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High elimination rates and concerns for horse welfare are important issues in endurance riding. Improved understanding of the causes of elimination could increase completion rates in this sport. We have identified pre-ride laboratory risk factors that enable an assessment of potential elimination before the ride. A longitudinal cohort study was performed among 49 healthy horses competing in the 160 km endurance ride at the 2016 World Championship of Endurance Riding in Samorin/Slovakia. Blood samples were taken before the event. For statistical evaluation, horses were categorized into three groups: finishers, lame horses, and metabolically eliminated horses. Risk factors were calculated for each group using multinominal logistic regression. δ-Aminolevulinic-dehydratase (ALAD), thiobarbituric acid reactive substances (TBARSs), iron, and serum amyloid A (SAA) were measured and did not show an impact on the race outcome, but elevated pre-ride superoxide dismutase (SOD) was shown to have an effect on lameness elimination (p = 0.011). It might serve as an indicator for withdrawing horses at risk of later elimination before endurance rides, ultimately resulting in lower elimination rates and an increase in overall horse welfare.

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