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Abstract

ABSTRACT:In the present study, Marumoside A isolated from Moringa oleifera, a traditional medicinal plant, was synthesized for the first time using trichloroacetimidate donor as a key step. The aglycone 4-hydroxy phenylacetamide was prepared from 4-hydroxyphenyl acetic acid using oxallyl chloride and aqueous ammonia. The lipid derivatives of Marumoside A were synthesized using different fatty amines. The anti-inflammatory activity of the Marumoside A and its lipid derivatives was evaluated for the inhibition of TNF-α and IL-1β secretion levels. Among all the synthesized molecules, the oleoyl amine lipid (unsaturated) derivative showed significant inhibition of TNF-α and IL-1β secretion with IC 50 value of 16.7 µM and 23.4 µM, respectively, when compared to Marumoside A and its saturated lipid derivatives. Further, the Marumoside A and its lipid derivatives also showed DPPH radical scavenging activity.

Chromosome‐scale assembly of the Moringa oleifera Lam. genome uncovers polyploid history and evolution of secondary metabolism pathways through tandem duplication

“…Epidemiological studies have consistently shown that high intake of flavonoids has protective effects against many infectious diseases and against cardiovascular, kidney and neurodegenerative diseases, cancers, and other age-related diseases (Kou et al, 2018;Leone et al, 2015;Siddhuraju & Becker, 2003). The presence of alkaloids, a family of cyclic organic secondary metabolic compounds containing nitrogen, has also been confirmed in The Plant Genome moringa leaves, notably marumoside A and marumoside B together with pyrrolemarumine-4″-O-α-L-rhamnopyranoside (Sahakitpichan et al, 2011), for which cardioprotective, anti-inflammatory and antihypertensive effects have been described (Dangi et al, 2002;Panda et al, 2013;Vudhgiri et al, 2016). Finally, glucosinolates, a family of sulfurcontaining secondary metabolites synthesized from amino acids in Brassicaceae species and related families from the Brassicales order, are also produced in all parts of the moringa plant, particularly in the form of aromatic glucosinolates derived from tryptophan and others from phenylalanine (Bennett et al, 2003).…”