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Fesel, Constantin; Goulart, Luis F; Neto, Adolfo Silva; Coelho, Alysson; Fontes, Cor Jésus Fernandes; Braga, Érika Martins; Vaz, Nelson M.

doi:10.1186/1475-2875-4-5

Cited by 17 publications

(9 citation statements)

References 46 publications

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“…The auto-antibody response was correlated with age and total IgG levels, suggesting a link with premunition [ 2 , 11 , 12 ]. These findings corroborate previous studies demonstrating a high IgG self-reactivity to brain antigens in asymptomatic P. falciparum and Plasmodium vivax patients [ 16 ]. However, levels of P. falciparum- specific antibodies were lower in AM than in MM.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, the plasma cytokine profiles were also examined to determine possible associations between such profiles and antibody responses. Unlike previous studies that assessed the protective role of auto-antibodies in malaria using a few antigens, the self-reactivity repertoire in the three groups of patients was evaluated using an approach that allowed the analysis of a large number of antigens [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The PANAMA-Blot method was used to determine the antibody repertoire to brain antigens as previously described [ 15 , 16 ]. PANAMA-Blot is a powerful approach allowing the analysis of the self-reactive antibodies repertoire against a large panel of antigens.…”

Section: Methodsmentioning

confidence: 99%

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Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3

Guiyedi

Bécavin

Herbert

et al. 2015

Malar J

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BackgroundMechanisms of acquired protection to malaria in asymptomatic Plasmodium falciparum carriers are only partially understood. Among them, the role plays by the self-reactive antibodies has not been clarified yet. In this study, the relationship between repertoires of circulating self-reactive and parasite-specific immunoglobulin G (IgG), their correlation with cytokine levels, and their association with protection against malaria was investigated in asymptomatic Plasmodium falciparum-infected Gabonese children.MethodsThe diversity of P. falciparum-specific antibody repertoire was analysed using a protein micro-array immunoassay, the total auto-antibody repertoire by quantitative immunoblotting and circulating cytokine levels were measured by ELISA in endemic controls (EC) and P. falciparum-infected children from Gabon with asymptomatic (AM) or mild malaria (MM). The association of self- and parasite-specific antibody repertoires with circulating cytokines was evaluated using single linkage hierarchical clustering, Kruskal – Wallis tests and Spearman’s rank correlation.ResultsChildren with AM exhibited an IgG response to merozoite surface protein 3 (MSP3) but not to MSP1-19, although their levels of total P. falciparum-specific IgG were similar to those in the MM group. Moreover, the asymptomatic children had increased levels of autoantibodies recognising brain antigens. In addition, a correlation between IL-10 levels and parasite load was found in AM and MM children. These two groups also exhibited significant correlations between plasma levels of IL-10 and IFN-γ with age and with total plasma IgG levels. IL-10 and IFN-γ levels were also associated with auto-antibody responses in AM.ConclusionsAltogether, these results indicate that a self-reactive polyclonal response associated with increased IgG to MSP3 and high plasma levels of IL-10 and IFN-γ may contribute to protective immune mechanisms triggered in asymptomatic P. falciparum infection in Gabonese children.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-015-0658-7) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3

Guiyedi

Bécavin

Herbert

et al. 2015

Malar J

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“…Third, ANA could be protective against schistosome infection, so that the ANA production preceded exposure to infection and provided protection against infection. This explanation has been proposed in malaria infections (reviewed in [43]) where cross-reactivity occurs between human and Plasmodium falciparum antigens and correlates with clinical protection against malaria [44]. While this hypothesis might explain the negative association between schistosome infection and ANA levels, it again, does not explain the rise in ANA levels following anti-helminthic treatment.…”

Section: Discussionmentioning

confidence: 98%

Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels

et al. 2011

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In animal experimental models, parasitic helminth infections can protect the host from auto-immune diseases. We conducted a population-scale human study investigating the relationship between helminth parasitism and auto-reactive antibodies and the subsequent effect of anti-helminthic treatment on this relationship. Levels of antinuclear antibodies (ANA) and plasma IL-10 were measured by enzyme linked immunosorbent assay in 613 Zimbabweans (aged 2–86 years) naturally exposed to the blood fluke Schistosoma haematobium. ANA levels were related to schistosome infection intensity and systemic IL-10 levels. All participants were offered treatment with the anti-helminthic drug praziquantel and 102 treated schoolchildren (5–16 years) were followed up 6 months post-antihelminthic treatment. ANA levels were inversely associated with current infection intensity but were independent of host age, sex and HIV status. Furthermore, after allowing for the confounding effects of schistosome infection intensity, ANA levels were inversely associated with systemic levels of IL-10. ANA levels increased significantly 6 months after anti-helminthic treatment. Our study shows that ANA levels are attenuated in helminth-infected humans and that anti-helminthic treatment of helminth-infected people can significantly increase ANA levels. The implications of these findings are relevant for understanding both the aetiology of immune disorders mediated by auto-reactive antibodies and in predicting the long-term consequences of large-scale schistosomiasis control programs.

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“…Plasmodium infections are also associated with a loss of T-cell control and subsequent B-cell disinhibition [20]. A similar polyclonal expansion is seen in P. vivax infection [21], possibly via similar mechanisms. Elevated levels of anti-cardiolipin antibodies are reported in both vivax and falciparum malaria; the metabolism of host phospholipids by Plasmodium with the subsequent exposure of altered lipid antigen on the host erythrocyte surface may serve as a trigger for antibody production [22].…”

Section: Discussionmentioning

confidence: 99%

False-positive rapid plasma reagin testing in patients with acute Plasmodium vivax malaria: A case control study

Maves

Dean

Gadea

et al. 2014

Travel Medicine and Infectious Disease

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Abstract: Background: Polyclonal B-cell activation is well known to occur in Plasmodium infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been demonstrated in other contexts.

Cited by 17 publications

References 46 publications

Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3

Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3

Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels

False-positive rapid plasma reagin testing in patients with acute Plasmodium vivax malaria: A case control study

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