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Allaire, Manon; Serée, Olivier; Coilly, Audrey; Houssel‐Debry, Pauline; Néau-Cransac, Martine; Pageaux, Georges‐Philippe; Dumortier, Jérôme; Altieri, Mario

doi:10.6002/ect.2018.0222

Cited by 1 publication

(1 citation statement)

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“…In contrast, reports of de novo HCC developing in a healthy donor liver, transplanted to a patient without a history of HCC, are extremely rare ( 2 – 16 ). A review of the case reports of HCC in transplanted livers reveals hepatitis B ( 5 – 7 , 10 , 15 , 17 ), C ( 2 , 8 , 10 – 13 , 18 ) and sclerosing cholangitis ( 18 , 19 ) as underlying diseases. Chronic viral hepatitis is an important factor in the development of HCC and, for both hepatitis B virus (HBV) and hepatitis C virus (HCV), there are many cases in which HCC develops after a long period of persistent infection.…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report

Sumiyoshi,

Takahara,

Shibuya

et al. 2024

Oncol Lett

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The development of tumors in livers transplanted from hepatitis B virus (HBV)-negative donors to patients with hepatitis B and cirrhosis is rare. The present study describes the case of a woman in her 60s who developed hepatocellular carcinoma (HCC) in her grafted liver, 19 years after transplantation, as well as a metachronous colorectal tumor. The pathological findings, including clinical, immunohistochemical and molecular results, are described in the present case report. The liver tumor was a conventional HCC and the colorectal tumor comprised a tubular adenocarcinoma. Immunohistochemistry of both tumors showed a loss of expression of mutL homolog 1 and postmeiotic segregation increased 2 in the tumor cells, confirming microsatellite instability-high (MSI-H) status. Furthermore, a molecular study detected the presence of genes located on the Y chromosome in the normal and tumor tissues of the liver, proving that the HCC occurred in the grafted liver. The present report also discusses that prolonged use of immunosuppressive drugs to prevent post-transplant rejection, poorly controlled diabetes mellitus and MSI-H may have contributed to the risk of tumor development.

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