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Surana, Rahul; Randall, Linda L.; Pyne, Abira; Vemuri, N. Murti; Suryanarayanan, Raj

doi:10.1023/a:1026199604374

Cited by 37 publications

(13 citation statements)

References 10 publications

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“…With increase in dextrose content, the moisture content leads to increase in free volume. The increased free volume between polymeric chains results in decreased T g [38][39][40][41]. The dextrose attract water molecules in DMSF films, so initial water content would promote secondary structural transition of DMSF films, because high ordered β-sheet crystallization only occurred when the crystallisable segments of silk fibroin obtain sufficient mobility by dextrose plasticization.…”

Section: Thermal Propertiesmentioning

confidence: 99%

Flexible silk fibroin films for wound dressing

et al. 2015

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In the present study, an effort has been made to create dextrose incorporated (5-15 % w/w) flexible silk fibroin films for wound dressing applications. The flexibility of silk fibroin films increases with increase in dextrose content. The elongation at break properties of dextrose modified silk fibroin (DMSF) films increases from 3.2 % to 40 % with increase in dextrose content. The glass transition temperature (T g ) of the films decreases from 176 o C to 155 o C with increase in dextrose content. This shows that dextrose is acting as plasticizer for silk fibroin films. The structural and morphological properties of dextrose modified silk films (DMSF) are characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) scanning electron microscopy (SEM) and atomic force microscopy (AFM). FTIR and XRD studies show that the dextrose content does not affect the crystalline structure of silk fibroin films. The surface roughness of the films also increases with increases in dextrose content in DMSF films. The addition of dextrose enhances the swelling and hydrophilicity of silk fibroin films. The adherence, proliferation and viability of L929 fibroblast cells cultured on DMSF films indicate that it has ability to support cell growth and proliferation as compared to SF film. The 15 % DMSF film showed significantly higher mass loss than SF film after 50 days of incubation in Protease XIV. Further, the data presented here constitute strong evidence that dextrose modified film has the great potential to be utilized as dermal wound dressing material.

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Section: Thermal Propertiesmentioning

confidence: 99%

Flexible silk fibroin films for wound dressing

et al. 2015

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“…It can be applied to observe the interaction between polymers and organic solvent systems under conditions approaching infinite dilution of the volatile component [11]. It is also used to determine the glass transition temperature (T g ) of polymers or amorphous pharmaceuticals and to study the plasticizing effect of water on these materials [12]. This is a good technique to determine the surface Lewis acid-base properties of insulating thermoplastic and thermosetting polymer materials [13] or to analyze the surface of multipurpose cellulosic office paper [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Tacticity of PMMA Adsorbed on Alumina and Silica on the Specific Entropy Change of Polymer by Inverse GC

2011

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Inverse gas chromatography (IGC) at infinite dilution is a powerful technique to characterize the superficial and interfacial properties of solid substrates as oxides, polymers or polymers adsorbed on oxides. It can also be used to determine the physicochemical properties and the transition phenomena of polymers. In this paper, IGC was used to determine the changes, as a function of temperature, of the specific free enthalpy DG a SP and deduce the specific entropy DS a SP of poly (methyl methacrylate) (PMMA) adsorbed on alumina or on silica for different tacticities of PMMA. The study of the surface properties of PMMA/SiO 2 and PMMA/Al 2 O 3 , revealed an important difference in the physicochemical behaviour of oxides covered by various concentrations of PMMA. This study also highlighted an important effect of the tacticity of the polymer on the specific entropy of PMMA adsorbed on oxides.

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“…There are several methods that could characterize water-excipient interactions, such as inverse gas chromatography,[13] NMR spectroscopy,[14] dielectric relaxation spectroscopy,[15] near infrared spectroscopy,[16] etc. Water induced crystallization can be followed by X-ray diffraction measurements.…”

Section: Measurement Techniquesmentioning

confidence: 99%

The effect of water on the solid state characteristics of pharmaceutical excipients: Molecular mechanisms, measurement techniques, and quality aspects of final dosage form

Szakonyi

Zelkó

2012

Int J Pharma Investig

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In this paper we give an overview about the interaction of water molecules with pharmaceutical excipients. Most of these excipients are amorphous or partially amorphous polymers and their characteristics are very sensitive to the water content. In the course of the manufacturing processes water sorption is possible, therefore in some cases it is important to strictly control the residual moisture content of a dosage form. There are several mechanisms of water sorption, like water is able to bind to polar groups of hygroscopic excipients and could also exist in the capillary system of amorphous excipients. Several techniques are available to characterise the states of water inside the materials and the effects of residual water on polymers. For this purpose water sorption measurements, differential scanning calorimetry and the Fourier-transform infrared spectroscopy are reviewed. The importance of water content and storage conditions of pharmaceuticals on the properties of the final dosage forms are also demonstrated with practical examples.

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Abstract: An IGC method was used (a) to determine the glass transition temperature of amorphous pharmaceuticals and (b) to quantify the plasticizing effect of water on multicomponent systems.

Cited by 37 publications

References 10 publications

Flexible silk fibroin films for wound dressing

Flexible silk fibroin films for wound dressing

Effect of the Tacticity of PMMA Adsorbed on Alumina and Silica on the Specific Entropy Change of Polymer by Inverse GC

The effect of water on the solid state characteristics of pharmaceutical excipients: Molecular mechanisms, measurement techniques, and quality aspects of final dosage form

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