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Based on the assumption of true moving bed processes it was demonstrated that integration of a racemization reaction into a continuous chromatographic process can improve the production of single enantiomers. In view of possible practical implementations, the analysis is extended to more realistic simulated moving bed (SMB) processes. Superstructures of SMB-based systems are defined that reflect the three general concepts of flow sheet, partial, and total process integration. Process candidates are generated by simultaneously optimizing process structure and operating conditions. Optimal process setups are determined under idealized conditions as a function of the purity requirement. The best performance is achieved by fully integrated processes. These are compared under more realistic conditions to units with side reactors. The results indicate that a simple fully integrated SMB system with three zones is a particularly promising new process option. The new concept is investigated in detail to identify relevant practical aspects.

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“…Furthermore, different types of units can be implemented like enzyme reactors [7,9] or electrochemical [29] reactors.…”

Section: Process Of Pumentioning

confidence: 99%

Integrated Simulated Moving Bed Processes for Production of Single Enantiomers

2011

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“…The microreactor as mentioned can be run in divided and undivided modes and for the synthesis of D-arabinose 31 from sodium D-gluconate 30 (Scheme 11), the divided cell mode was chosen [35]. A schematic integrated system and a simulated concentration profile is shown in Figure 10.…”

Section: Advantages Of Electrochemical Microreactors (Ecmr's)mentioning

confidence: 99%

Electrochemical Synthesis in Microreactors

2014

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“…Schmidt-Traub and co-workers reported a new continuous process, combining electrochemical reaction and chromatographic simulated-moving-bed (SMB) separation [51]. For the development of this novel continuous process the electrochemical reaction, took place in an ECMR which was then coupled to the SMB plant.…”

Section: Anodic Decarboxylation Of Glyconate To Arabinosementioning

confidence: 99%

Electrochemical microstructured reactors: design and application in organic synthesis

et al. 2009

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The use of micro structured reactors is an accepted technology in fundamental chemical research as well as in industrial applications. The application of electrochemical microreactors (ECMR) has not attracted as much attention as continuously performed reactions in a confined space. Nevertheless ECMRs are in use to perform electro-organic reactions. In this review, different aspects of ECMRs with structured electrodes and interelectrode distances of mainly B100 lm are investigated and discussed, together with various manufacturing techniques and prototypes described therein. Based on representative examples described in various publications for electrolysis (for direct and indirect electrolysis) advantages and disadvantages of electrochemical microreactors are presented and compared with those of conventional electrochemical reactors. List of symbolsA e Electrode surface A e = Lw (m 2 ) a e Volume specific electrode area (m -1 ) a inv Specific investment costs (€/m 2 h) A, B, C, D Reagent or product of the electrochemical reaction b A Kinetic constant of the reaction involving reagent A (V -1 ) b inv Current costs (€/kW h) C A Concentration of reagent A (mol m -3 or mol L -1 ) D Inter-electrode gap (m) d e Electrode thickness (m) d eq Equivalent or hydraulic diameter D Diffusion coefficient (m 2 s -1 ) E c , E a Cathodic, anodic potential (V) E c e ; E a e Cathodic, anodic equilibrium potential (V) E cell Cell voltage (V) E tn Thermoneutral cell voltage F Faraday constant (96,486 A s mol -1 ) i Current density (A m -2 )

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Cited by 14 publications

References 14 publications

Integrated Simulated Moving Bed Processes for Production of Single Enantiomers

Integrated Simulated Moving Bed Processes for Production of Single Enantiomers

Electrochemical Synthesis in Microreactors

Electrochemical microstructured reactors: design and application in organic synthesis

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