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Смирнов, А. Н.; Pokrovskaya, E. V.; Левина, И. С.; Куликова, Л. Е.; Kamernitzky, A. V.; Шевченко, В. П.

doi:10.1023/a:1010219617134

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…In addition to the receptors, some representatives of the pregna-D'-pentarane series exhibited affinity to other two proteins, which we named pentaranofilins [11,13,14]. One of them was found in rat uterus, and another, in rat blood.…”

Section: The Interaction Of Pregna-d'-pentaranes With the Classical Pmentioning

confidence: 99%

Pregna-D′-pentaranes, Progestins and Antiprogestins: II. Pathways and Realization Mechanisms of Separate Biological Functions of Steroid Hormones

Kamernitzky

Левина

2005

Russ J Bioorg Chem

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The manner in which multifunctional steroid hormones realize their separate biological functions in mammal organisms is considered. This study is carried out on the basis of a systematic set of progesterone analogues, which we developed and described in part I of the review. This set has for the first time enabled the use of compounds of this type for studying the pathways and realization mechanisms of separate biological functions of steroid hormones. The interaction of pregna-D'-pentaranes with the classical progesterone receptor, their independent influence on the myometrium and ovogenesis, and some nonclassical effects are described. A scheme of realization is suggested for the biological functions already known, newly discovered, and presumed by us that, during pregnancy, are fulfilled in mammal organisms by progesterone and its nearest metabolite, dihydroprogesterone.

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Section: The Interaction Of Pregna-d'-pentaranes With the Classical Pmentioning

confidence: 99%

Pregna-D′-pentaranes, Progestins and Antiprogestins: II. Pathways and Realization Mechanisms of Separate Biological Functions of Steroid Hormones

Kamernitzky

Левина

2005

Russ J Bioorg Chem

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3- and 19-Oximes of 16α,17α-cyclohexanoprogesterone derivatives: Synthesis and interactions with progesterone receptor and other proteins

et al. 2008

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Approaches to the design of selective ligands for membrane progesterone receptor alpha

Lisanova

Shchelkunova

Морозов

et al. 2013

Biochemistry Moscow

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A number of progesterone derivatives were assayed in terms of their affinity for recombinant human membrane progesterone receptor alpha (mPRα) in comparison with nuclear progesterone receptor (nPR). The 16α,17α-cycloalkane group diminished an affinity of steroids for mPRα without significant influence on affinity for nPR, thus rendering a prominent selectivity of ligands for nPR. On the contrary, substitution of methyl at C10 for ethyl or methoxy group moderately increased the affinity for mPRα and significantly lowered the affinity for nPR. A similar but even more prominent effect was observed upon substitution of the 3-oxo group for the 3-O-methoxyimino group. A significant preference towards mPRα was also rendered by the 17α-hydroxy group and additional C6-C7-double bond. The data suggest that the modes of ligand interaction with mPRα and nPR in the C3 region of the steroid molecule are different. One can speculate that combination of the above substitutions at C17, C10, C6, and C3 may give ligand(s) with high specificity towards mPRα over nPR.

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Cited by 3 publications

References 6 publications

Pregna-D′-pentaranes, Progestins and Antiprogestins: II. Pathways and Realization Mechanisms of Separate Biological Functions of Steroid Hormones

Pregna-D′-pentaranes, Progestins and Antiprogestins: II. Pathways and Realization Mechanisms of Separate Biological Functions of Steroid Hormones

3- and 19-Oximes of 16α,17α-cyclohexanoprogesterone derivatives: Synthesis and interactions with progesterone receptor and other proteins

Approaches to the design of selective ligands for membrane progesterone receptor alpha

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