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Mg, Aman; Sa, Armstrong

doi:10.1023/a:1017203929453

Cited by 3 publications

References 7 publications

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Secretin as a Treatment for Autism: A Review of the Evidence

Esch

Carr

2004

J Autism Dev Disord

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Secretin is used in the United States for diagnosis of pancreatic gastrointestinal (GI) dysfunction and disease. Repeated therapeutic use has not been approved. Widespread interest in secretin as a treatment for autism followed media reports of behavioral improvements in an autistic child who received the hormone during a GI diagnostic procedure. International demand for secretin soared in the absence of experimental evidence of its efficacy for autism. This review presents a brief history of secretin's rise to popularity and summarizes research on secretin as a treatment for autism. Seventeen studies are reviewed comparing the effects of secretin forms, dosage levels, and dosing intervals on outcome measures with approximately 600 children. Twelve of 13 placebo-controlled studies failed to demonstrate the differential efficacy of secretin. Implications for advocating treatment in the absence of empirical evidence are discussed.

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Secretin as a Treatment for Autism: A Review of the Evidence

Esch

Carr

2004

J Autism Dev Disord

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Autism spectrum disorders: Update of evaluation and treatment

Mikhail

King

2001

Curr Psychiatry Rep

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Autistic spectrum disorders are a group of neurodevelopmental conditions that are increasingly capturing the attention of clinicians and investigators. New insights from genetics and neuropathophysiology of autism will increasingly inform treatment. Presently, individualized treatment approaches typically include a mix of behavioral and, occasionally, pharmacotherapeutic strategies. Concerning the latter, exquisite sensitivity to medication is not uncommon in some children with autism.

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