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Yavorskaya, N. P.; Голубева, И. С.; Kubasova, I. Yu.; Ovchinnikov, Alexander V.; Plekhanova, N. G.; Glibin, E. N.

doi:10.1023/a:1012337503345

Cited by 5 publications

(3 citation statements)

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“…Combining the AMD chromophore with crown groups in the side chains should give different specificities of metal cation binding and possibly to different antitumor activities. It was found that the activity of compounds with five‐membered crown ether side chains showed antitumor activity similar to that of AMD, whereas derivatives with side chains containing six‐membered crown ethers abolished all cytotoxic effects in two model systems: MOLT‐3 leukemia cells78 and in mice bearing Ca755 adenocarcinoma 79…”

Section: Biological Activity Of Crown Ethersmentioning

confidence: 99%

“…Several studies were carried out using crown ether derivatives of actionomycin D (AMD) containing benzo‐15‐crown‐5 and benzo‐18‐crown‐6 groups attached by amide bonds 78. 79 The rationale for these studies is based on the characteristic of AMD to act as an ionophore antibiotic consisting of a phenoxazone chromophore substituted with two cyclic pentapeptide lactone rings. The biological activity involves intercalation of the planar phenoxazone chromophore into GC‐rich sequences of DNA, while the pentapeptide rings lie in the minor groove.…”

Section: Biological Activity Of Crown Ethersmentioning

confidence: 99%

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Biomedical Potentials of Crown Ethers: Prospective Antitumor Agents

2008

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Crown ethers are of enormous interest and importance in chemistry, biochemistry, materials science, catalysis, separation, transport and encapsulated processes, as well as in the design and synthesis of various synthetic systems with specific properties, diverse capabilities, and programmable functions. Classical crown ethers are macrocyclic polyethers that contain 3-20 oxygen atoms separated from each other by two or more carbon atoms. They are exceptionally versatile in selectively binding a range of metal ions and a variety of organic neutral and ionic species. Crown ethers are currently being studied and used in a variety of applications beyond their traditional place in chemistry. This review presents additional applications and the ever-increasing biomedical potentials of these intriguing compounds, with particular emphasis on the prospects of their relevance as anticancer agents. We believe that further research in this direction should be encouraged, as crown compounds could either induce toxicities that are different from those of conventional antitumor drugs, or complement drugs in current use, thereby providing a valuable adjunct to therapy.

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Section: Biological Activity Of Crown Ethersmentioning

confidence: 99%

Section: Biological Activity Of Crown Ethersmentioning

confidence: 99%

Biomedical Potentials of Crown Ethers: Prospective Antitumor Agents

2008

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“…1) exhibits the highest antitumor activity in this series [17]. At the same time, this compound exhibits unique spectral properties indicating the formation of ordered aggregate structures in aqueous solutions containing K + and Na + ions.…”

Section: Introductionmentioning

confidence: 89%

Formation of the aggregates of actinocin derivatives containing 4′-benzo-15-crown-5 radicals in amide groups and their interaction with a DNA molecule

Sedova

Urusova

2011

J Struct Chem

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Methods of spectrophotometry, spectropolarimetry, and viscometry are used to study the self-organization in the solution of crown-containing actinocin derivative (I) exhibiting antitumor activity and the interaction of the formed aggregates with a DNA molecule. The presence of the 4′-benzo-15-crown-5 radical in the structure of the studied compound determines the observed differences in its complexation with Na + and K + ions. The process of aggregation in the presence of K + ions is accompanied by a shift of the long-wave band in the absorption spectrum to short-wave (the formation of H type aggregates) or long-wave (the formation of J type aggregates) regions depending on the K + ion concentration in the solution. In the presence of Na + ions, regardless of their concentration in the solution, J type aggregates form. A scheme of complex formation and their mutual transformations with changes in the ionic composition of the medium is proposed. A study of the interaction of this compound with DNA shows that in the presence of K + ions it binds to the DNA molecule in the form of monomers and/or dimers without producing large supramolecular aggregates. The H and J structures formed in K + -containing solutions of compound I are broken in the interaction with DNA. If a solution of compound I is added to a DNA solution containing Na + ions, the J type aggregates are formed directly on the surface of the DNA molecule. At the same type, the J structures originally formed in the Na + -containing solution of compound I practically do not interact with DNA. A study of this system shows that the introduction of the crown group in the compound molecule with a heterocyclic chromophore provides the opportunity to affect its affinity and binding to the DNA molecule by means of the ionic composition of the medium.

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Supramolecules in Pharmaceutical Science: A Brief Overview

Goel

Kumar

2022

Pharmaceutical Applications of Supramolecules

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Cited by 5 publications

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Biomedical Potentials of Crown Ethers: Prospective Antitumor Agents

Biomedical Potentials of Crown Ethers: Prospective Antitumor Agents

Formation of the aggregates of actinocin derivatives containing 4′-benzo-15-crown-5 radicals in amide groups and their interaction with a DNA molecule

Supramolecules in Pharmaceutical Science: A Brief Overview

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