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Weigert, Monika; Feichtinger, Wilfried; Kulin, Sandor; Kaali, Steven G.; Dorau, Petra; Bauer, Péter

doi:10.1023/a:1013160905497

Cited by 16 publications

(6 citation statements)

References 17 publications

(15 reference statements)

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“…Some studies on season and IVF outcomes have found no association [14][15][16][17][18], while some have suggested higher implantation and livebirth rates for IVF cycles started in the spring and summer [19][20][21]. Other studies have suggested higher positive IVF outcomes for cycles started in the fall and winter [22,23]. To improve understanding of the relationship between seasonal variation and IVF success, we investigated the relationship between season, temperature, and day length at time of oocyte retrieval in a large cohort of more than 6000 IVF cycles performed at one IVF center in Massachusetts over a 6-year period.…”

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confidence: 99%

Seasonal variation, temperature, day length, and IVF outcomes from fresh cycles

Farland

Correia

Missmer

et al. 2020

J Assist Reprod Genet

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Purpose It is known that delivery rates from spontaneous conception vary according to season which may be due to cultural or environmental factors; however, conflicting data exist regarding whether outcomes from IVF are also seasonally dependent. The present study was designed to test the hypothesis that the season at oocyte retrieval is associated with livebirth after fresh transfer. Methods Dates of oocyte retrieval for all autologous cycles in our IVF program between January 2012 and December 2017 were categorized by season. Dates were linked to local temperature (min, max, average) and day length obtained from meteorological records. Average maximum temperature and day length were categorized into tertiles. Multivariable logistic regression, adjusted for age and quadratic age, were used to model odds (aOR) of implantation, clinical pregnancy, spontaneous abortion, and livebirth. Results Patient characteristics were similar across seasons. As expected, temperature and day length varied by season. When compared with cycles started during winter, there was no difference in the age-adjusted odds of livebirth for the other three seasons (spring: aOR: 0.97, 95%

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confidence: 99%

Seasonal variation, temperature, day length, and IVF outcomes from fresh cycles

Farland

Correia

Missmer

et al. 2020

J Assist Reprod Genet

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“…In an earlier retrospective analysis of 8184 ART cycles conducted in Europe, Weigert et al . [ 18 ] reported significantly higher pregnancy rates in the colder months September–April (32.2%) versus May–August (28.5%). Investigators concluded that the difference may be attributed to the difference in semen parameters in different seasons.…”

Section: Discussionmentioning

confidence: 99%

“…In a quest for evaluating the effects of seasonal variation on ART, investigators have performed number of studies, however, most of the studies report conflicting results. [ 15 16 17 18 ] While few studies reported poor fertilization and implantation rates in autumn and higher pregnancy rates following ART in spring,[ 15 16 ] others reported significantly higher number of ART conceptions in the winter months. [ 17 18 ] In addition, some investigators further reported no significant difference in fertilization, clinical pregnancy, or LBRs following ART in different seasons.…”

Section: Introductionmentioning

confidence: 99%

“…[ 15 16 17 18 ] While few studies reported poor fertilization and implantation rates in autumn and higher pregnancy rates following ART in spring,[ 15 16 ] others reported significantly higher number of ART conceptions in the winter months. [ 17 18 ] In addition, some investigators further reported no significant difference in fertilization, clinical pregnancy, or LBRs following ART in different seasons. [ 19 20 21 ] The lack of consistency in the results may be attributed to the heterogeneity in study population, ART protocols, ethnicity, and regional variations in types and duration of seasons.…”

Section: Introductionmentioning

confidence: 99%

“…It is important to note that most of the studies are reported in European[ 17 18 19 ] and Middle eastern[ 15 20 ] population as well as a study from China. [ 21 ] There are no published studies on effects of seasonal variations on ART outcomes from South Asia.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal Influence on Assisted Reproductive Technology Outcomes

Singh

Joseph

Karuppusami

et al. 2021

Journal of Human Reproductive Sciences

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Background: It is well known that seasonal variations influence natural conception and birth rates variably in different populations. It has been hypothesised that similar seasonal influences may affect treatment outcomes following assisted reproductive technology (ART). However, most studies report conflicting results. Aim: The aim of the study is to elucidate whether seasonality had any impact on the treatment success of the ART program. Study Setting and Design: We conducted a retrospective cohort study at a university-level tertiary care hospital in South India. Materials and Methods: All couples who underwent ART between January 2012 and December 2016 were included in the study. We divided the study population into three groups based on the seasonal differences experienced in our region. The primary outcome was live birth rate (LBR). Statistical Analysis: Univariate and multiple logistic regression models were used to compare outcomes and results reported as odds ratio (OR) and 95% confidence interval (CI). Results: Univariate analysis revealed no significant difference in LBR in monsoon season (174/651, 26.7% vs. 83/319, 26.0%; OR 1.04, 95% CI 0.77,1.41; P = 0.81) as compared to summer. However, LBR was significantly higher in winter season (114/341, 33.4% vs. 83/319, 26.0%; OR 1.43; 95% CI: 1.02, 2.00; P = 0.04). Further, multivariate analysis following adjustment for various confounding factors revealed no significant statistical difference in LBR in monsoon (adjusted odds ratio [aOR], 0.92; 95% CI: 0.66, 1.26; P = 0.59) or winter (aOR 1.32; 95% CI: 0.92, 1.88; P = 0.13) as compared to summer season. Conclusion: The current study found no significant effect of seasonal variation on LBR following ART.

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Culture Systems: Physiological and Environmental Factors That Can Affect the Outcome of Human ART

Rieger¹

2012

Methods in Molecular Biology

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Many aspects of the embryo culture environment have been shown to affect embryo development and the subsequent outcomes of human ART. It is now becoming increasingly evident that embryo and later development can be affected by events and conditions that occur before, perhaps long before, the oocytes and sperm are collected and brought together in the ART laboratory. These include diet and metabolic disorders, general health and disease, physical and psychological stress, exposure to environmental estrogens and other toxins, pharmaceuticals, alcohol, smoking, and drug abuse. This paper discusses the known and potential effects of season of the year (or temperature) and environmental air pollution on the outcomes of human ART. It may be useful to advise ART patients to avoid high environmental temperature and air pollution. In addition, it is important for clinical embryologists to recognize that adverse outcomes may result from such exposures, and to incorporate this into the analysis of clinic data for the purposes of quality management.

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Abstract: The observed weekly rhythm for oocyte pick-ups is certainly due to preprogrammed ovarian stimulation used in our IVF programs. Age as well as the number of embryos transferred are the main influencing factors on a positive outcome and more predictive than seasonal aspects.

Cited by 16 publications

References 17 publications

Seasonal variation, temperature, day length, and IVF outcomes from fresh cycles

Seasonal variation, temperature, day length, and IVF outcomes from fresh cycles

Seasonal Influence on Assisted Reproductive Technology Outcomes

Culture Systems: Physiological and Environmental Factors That Can Affect the Outcome of Human ART

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