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Griesinger, G.; Franke, Katharina; Kinast, C; Kutzelnigg, Alexandra; Riedinger, Sandra; Kulin, Sandor; Kaali, Steven G.; Feichtinger, Wilfried

doi:10.1023/a:1014837811353

Cited by 44 publications

(6 citation statements)

References 36 publications

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“…A study determined the concentrations of carotenoids, retinol and α-tocopherol in follicular fluid and plasma in women undergoing IVF programs [ 106 ], and showed that differences between plasma and follicular fluid were greater for β-carotene and lycopene (<20% of plasma concentration) [ 106 ]. Moreover, an exogenous stress, such as cigarette smoke, influenced the level of β-carotene in women undergoing IVF treatments, with smokers having significantly lower levels of follicular fluid β-carotene in comparison to non-smokers [ 107 ]. In accordance, the mean β-carotene levels in follicular fluid and plasma of smokers were found to be lower compared to the levels in the non-smokers group [ 108 ].…”

Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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For most infertile couples, in vitro fertilization (IVF) represents the only chance to conceive. Given the limited success of IVF procedures, novel approaches are continuously tested with the aim of improving IVF outcomes. Growing attention is devoted today to the potential benefit of natural antioxidants in the optimization of infertility treatments. This review summarizes current data in this context, focusing on both experimental studies on oocytes/embryos and clinical trials on antioxidants supplementation. Based on information gained from experimental studies, antioxidant supplementation may have beneficial effects on IVF outcomes in terms of quality and cryotolerance of in vitro produced embryos, together with positive effects on in vitro maturation oocytes and on early embryonic development. Unfortunately, from the clinical side, there is a paucity of evidence favoring the protective qualities of antioxidants. Among the antioxidants considered, coenzyme Q10 may be regarded as one of the most promising for its positive role in rescuing the oxidative stress-induced damages, but further data are needed. It is concluded that further trials are necessary to characterize the potential clinical value of antioxidants in IVF treatments.

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Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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“…Increase in progesterone levels Henmi et al [ 124 ] 2. Increase in clinical pregnancy rates Vitamin C Double blind, placebo-controlled, RCT Women (<40y) undergoing first IVF-ET cycles (n = 620) 1 g or 5 g or 10 g ascorbic acid +30 mg Dydrogesteron x 14 days after follicle aspiration for IVF-ET Placebo (Lactose + citric acid +30 mg Dydrogesteron) No difference in clinical pregnancy and implantation rates Griesinger et al [ 125 ] Myo-inositol + folic acid Placebo-controlled, RCT Infertile PCOS patients undergoing ovulation induction for ICSI (n = 60) 4 g myo-inositol +400 μg folic acid (n = 30) 400 μg folic acid only (n = 30) Reduced germinal vesicles and degenerated oocytes without compromising the number of oocytes retrieved at ovum pick-up Papaleo et al [ 126 ] Myo-inositol + folic acid Double blind Infertile PCOS patients undergoing ovulation induction for IVF or ICSI (n = 34) 4 g of myo-inositol +400 μg of folic acid, continuously for 3 months 400 μg of folic acid only 1. Greater number of oocytes recovered during pick up Ciotta et al [ 127 ] 2.…”

Section: Antioxidants As Ameliorating Agentsmentioning

confidence: 99%

“…Ascorbic acid taken as dietary intake [ 154 , 155 ] or oral therapy, improves spermatozoa quality [ 109 , 110 ]. In a large, placebo-controlled, double blind RCT, vitamin C supplementation for a period of 14 days starting on the day of follicle aspiration in women undergoing IVF-ET showed no improvement in clinical pregnancy or implantation rates [ 125 ]. However, smaller prospective studies showed that oral vitamin C supplementation in women, either undergoing IVF-ET treatment [ 123 ] or with luteal phase defects [ 124 ], lead to increased pregnancy rates.…”

Section: Antioxidants As Ameliorating Agentsmentioning

confidence: 99%

Utility of antioxidants during assisted reproductive techniques: an evidence based review

Agarwal

Durairajanayagam

Plessis

2014

Reprod Biol Endocrinol

188

134

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Assisted reproductive technology (ART) is a common treatment of choice for many couples facing infertility issues, be it due to male or female factor, or idiopathic. Employment of ART techniques, however, come with its own challenges as the in vitro environment is not nearly as ideal as the in vivo environment, where reactive oxygen species (ROS) build-up leading to oxidative stress is kept in check by the endogenous antioxidants system. While physiological amounts of ROS are necessary for normal reproductive function in vivo, in vitro manipulation of gametes and embryos exposes these cells to excessive ROS production either by endogenous or exogenous environmental factors. In this review, we discuss the sources of ROS in an in vitro clinical setting and the influence of oxidative stress on gamete/embryo quality and the outcome of IVF/ICSI. Sources of ROS and different strategies of overcoming the excessive generation of ROS in vitro are also highlighted. Endogenously, the gametes and the developing embryo become sources of ROS. Multiple exogenous factors act as potential sources of ROS, including exposure to visible light, composition of culture media, pH and temperature, oxygen concentration, centrifugation during spermatozoa preparation, ART technique involving handling of gamete/embryo and cryopreservation technique (freeze/thawing process). Finally, the use of antioxidants as agents to minimize ROS generation in the in vitro environment and as oral therapy is highlighted. Both enzymatic and non-enzymatic antioxidants are discussed and the outcome of studies using these antioxidants as oral therapy in the male or female or its use in vitro in media is presented. While results of studies using certain antioxidant agents are promising, the current body of evidence as a whole suggests the need for further well-designed and larger scale randomized controlled studies, as well as research to minimize oxidative stress conditions in the clinical ART setting.

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“…A prospective cohort study [ 55 ] failed to demonstrate a significant improvement of ART outcomes after oral treatment of women with vitamin C during ovarian stimulation. Similarly, in an RCT using oral treatment with vitamin C for 14 days beginning with the day of oocyte retrieval, no improvement of implantation and clinical pregnancy rate was achieved [ 56 ]. As to vitamin E, another direct antioxidant agent, an observational study demonstrated a positive correlation of endogenous vitamin E concentrations in serum and follicular fluid with the number of metaphase II oocytes and some morphological parameters of embryo quality after IVF [ 57 ], but experience with therapeutic use of exogenous vitamin E is currently lacking.…”

Section: Resultsmentioning

confidence: 99%

Towards Personalized Antioxidant Use in Female Infertility: Need for More Molecular and Clinical Studies

Tesarik

2021

Biomedicines

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Treatment with antioxidants is increasingly used to slow down aging processes in different organs of the human body, including those implicated in female fertility. There is a plethora of different natural, synthetic or semi-synthetic medicines available on the market; most of them can be purchased without medical prescription. Even though the use of antioxidants, even under conditions of auto-medication, was shown to improve many functions related to female infertility related to oxidative stress, the lack of medical control and supervision can lead to an overmedication resulting in an opposite extreme, reductive stress, which can be counterproductive with regard to reproductive function and produce various adverse health effects in general. This paper reviews the current knowledge relative to the effects of different antioxidants on female reproductive function. The persisting gaps in this knowledge are also highlighted, and the need for medical supervision and personalization of antioxidant prescription is underscored.

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Abstract: There was no clinical evidence of any beneficial effect, as defined by main outcome measures, of ascorbic acid on IVF-ET. Our data suggest there is no obvious value of high dosed intake of vitamin C during luteal phase in infertility treatment.

Cited by 44 publications

References 36 publications

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Utility of antioxidants during assisted reproductive techniques: an evidence based review

Towards Personalized Antioxidant Use in Female Infertility: Need for More Molecular and Clinical Studies

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