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Abstract

The novel Co (II) and Zn (II) complexes have been synthesized by reaction of CoCl 2 /ZnCl 2 with Schiff bases of benzoyl derivative of 3-methyl-1-phenyl-2-pyrazoline-5-one and sulfa drugs in 1:2 ratio. The synthesized complexes were screened/tested for their antimicrobial activity against pathogenic bacterial strains i.e. E. coli, Staphylococcus aureus strain I, Staphylococcus aureus strain II, Staphylococcus aureus strain III, Vibrio cholera, Gram positive Cocci, Gra am positive Bacillus, Gram negative Bacillus, Bacillus subtilis and Salmonella typhimurium. It was found that metal complexes have more antimicrobial activity than their parent Schiff bases. Complexes of Schiff base ligand sulfamerazine and bmphp (L 2) were also found to be more active. INTRODUCTION: Schiff bases containing azomethine (imine) group (-RC=N-) are usually prepared by the condensation of a primary amine with an active carbonyl compound 1, 2. The formation of variety of metal complexes with such ligands, indicate the spectacular progress in coordination and bioinorganic chemistry. Schiff base complexes of transition metals containing ligand with N, O donors exhibit interesting biological activity. It has now been observed that some of these drugs show increased biological activity when administered in the form of metal complexes 3, 4 .