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Abstract

The reaction of diazotization of 2,4-diamino-5,10-dioxo-1,5,10,10atetrahydrobenz[g]quinoline-3-carbonitrile (1) afforded 4-amino-2-(chlorodiazenyl)-5,10dioxo-1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile (2) as a versatile building block for the design and synthesis of some novel benzo[g]quinolone systems. The structure of the newly synthesized compounds has been confirmed by IR, 1 H NMR, 13 C NMR, mass spectral and elemental analysis. Furthermore, some selected compounds were screened for their in vitro anti-cancer activity against A-549, HT-29 and MKN-45 cancer cells. The results declared that most of the synthesized compounds are endued with high anti-tumor activity; compounds (4), ( 6) and (7) presented the highest cytotoxic activity against lung cancer A-549, gastric cancer MKN-45 and colon adenocarcinoma cell lines, respectively.