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Aramaki, Yukihiko; Tomizawa, Hitoshi; Hara, Toshifumi; Yachi, Kiyoto; Kikuchi, Hiroshi; Tsuchiya, Satoshi

doi:10.1023/a:1018936806278

Cited by 92 publications

(10 citation statements)

References 14 publications

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“…Regarding liposome size, Aramaki et al reported that multilamellar liposomes (MLV) larger than 374 nm in size were taken up through rat Peyer's patches after oral administration using isolated tissues. 28 The MLV liposomes have been used in many cases for oral administration, [11][12][13][14][15] while REV liposomes have not.…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of Recombinant Human Erythropoietin in Liposomes in Rats: Influence of Lipid Composition and Size of Liposomes on Bioavailability

Maitani

Hazama

Tojo

et al. 1996

Journal of Pharmaceutical Sciences

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Intestinal absorption of recombinant human erythropoietin (Epo) encapsulated in liposomes (Epo/liposomes) was examined by measuring the pharmacological effects of Epo after oral administration in rats. Circulating reticulocyte counts after oral administration of Epo/liposomes showed a profile different from that after intravenous administration. Epo/liposomes 0.1 micron in diameter were absorbed more effectively than those 0.2 micron in diameter. In the 0.1 micron Epo/liposomes composed of dipalmitoylphosphatidylcholine (DPPC) and soybean-derived sterols (SS), cholesterol (Ch), or soybean-derived sterylglucosides (SG), DPPC/SS (in molar ratio 7/2) and DPPC/Ch (7/2) showed higher efficiency in intestinal absorption than DPPC/Ch (7/4) and DPPC/SG (7/2) at a low dose by the sysmex method. Pharmacological availabilities for oral administration of Epo/liposomes were 0.74-31% and 3.3-30% as evaluated by circulating reticulocyte counts and percentage circulating reticulocytes of erythrocytes, respectively, in comparison to those for intravenous administration of the same dose.

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Section: Discussionmentioning

confidence: 99%

Oral Administration of Recombinant Human Erythropoietin in Liposomes in Rats: Influence of Lipid Composition and Size of Liposomes on Bioavailability

Maitani

Hazama

Tojo

et al. 1996

Journal of Pharmaceutical Sciences

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“…Peyer's patches are an important absorption pathway for antigenic or lipophilic drugs as this route can be used for targeting (Aramaki et al, 1993). Peyer's patches are an important absorption pathway for antigenic or lipophilic drugs as this route can be used for targeting (Aramaki et al, 1993).…”

Section: Animal Experimentsmentioning

confidence: 99%

“…The formulations are designed for oral administrations. Peyer's patches are an important absorption pathway for antigenic or lipophilic drugs as this route can be used for targeting (Aramaki et al, 1993). In this and previous studies, the immunological properties of lipids in liposomes and nanocochleates were utilized (De Libero, Collmann, & Mori, 2009).…”

Section: Animal Experimentsmentioning

confidence: 99%

Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma

Çoban

Değim

Yılmaz³

et al. 2019

Drug Development Research

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The main challenges in treating cancer using chemotherapeutics are insufficient dose at the target site and the development of drug resistance, while higher doses can induce side effects by damaging nontarget tissues. Combinatorial drug therapy may overcome these limitations by permitting lower doses and more specific targeting, thereby mitigating drug resistance and nontarget side effects. Recent reports indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) have anticancer potential and can be used together with conventional chemotherapeutics to improve efficacy and safety. In the present study, imatinib mesylate and dexketoprofen trometamol were selected as model drugs to develop targeted surface-modified liposome and nanocochleate formulations for fibrosarcoma treatment. The physicochemical properties and in vitro efficacy of various formulations were evaluated by measurement of particle size distribution, polydispersity index, zeta potential, encapsulation efficiency, diffusion through Caco-2 cells, and toxicity in culture. Selected formulations were then evaluated in fibrosarcoma-bearing model mice by histopathological observations and tyrosine kinase receptor inhibition assays.The most effective formulation on the fibrosarcoma model was a PEGylated nanocochleate formulation. These findings provide a foundation for developing more effective formulations and chemotherapeutic strategies for the treatment of fibrosarcoma and other types of cancer.

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“…Cell targeting studies have been investigated and produced significant data and observations of how antigen presentation plays a significant role. Aramaki et al investigated the utilization of liposomes as carriers for antigens related to gut-associated lymphoid tissue and their uptake by rat Peyer’s patches [ 63 ]. Preferential uptake was observed for liposomes in the rat Peyer’s patches than non-patch tissues, specifically for DSPC:PS:Chol liposomes.…”

Section: Liposome-immune Cell Interactions To Improve Vaccine Effectimentioning

confidence: 99%

Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines

Serrano

Burkhart

2017

J Nanobiotechnol

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Vaccinology is one of the most important cornerstones in modern medicine, providing better quality of life. The human immune system is composed of innate and adaptive immune processes that interplay when infection occurs. Innate immunity relies on pathogen-associated molecular patterns which are recognized by pathogen recognition receptors localized in antigen presenting cells. After antigen processing and presentation, CD4+ T cell polarization occurs, further leading to B cell and CD8+ activation and humoral and cell-mediated adaptive immune responses. Liposomes are being employed as vaccine technologies and their design is of importance to ensure proper immune responses. Physicochemical parameters like liposome size, charge, lamellarity and bilayer fluidity must be completely understood to ensure optimal vaccine stability and efficacy. Liposomal vaccines can be developed to target specific immune cell types for the induction of certain immune responses. In this review, we will present promising liposomal vaccine approaches for the treatment of important viral, bacterial, fungal and parasitic infections (including tuberculosis, TB). Cationic liposomes are the most studied liposome types due to their enhanced interaction with the negatively charged immune cells. Thus, a special section on the cationic lipid dimethyldioctadecylammonium and TB is also presented.

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Cited by 92 publications

References 14 publications

Oral Administration of Recombinant Human Erythropoietin in Liposomes in Rats: Influence of Lipid Composition and Size of Liposomes on Bioavailability

Oral Administration of Recombinant Human Erythropoietin in Liposomes in Rats: Influence of Lipid Composition and Size of Liposomes on Bioavailability

Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma

Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines

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