Abstract:A1 .ne and pyrimidine metabol for antiviral chemotherapy viral hepatitis Shaw T, Locarnini SA. Hepatic purine and pyrimidine metabolism: implications for antiviral chemotherapy of viral hepatitis. Liver 1995: 15: 169-184. 0 Munksgaard, 1995 Abstract: The use of nucleoside analogues as antiviral agents is expanding. For most nucleoside analogues, intracellular phosphorylation is the major prerequisite for activity. Antiviral activity may be limited by poor uptake, absence of appropriate activating enzymes, cata… Show more
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