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Synthesis of thiazolo[3,2-a]pyrimidines based on 4-aryl-substituted 3,4-dihydro-pyrimidine(1H)-2-thiones and the crystal structure of ethyl 5-(2,4-dimethoxyphenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo-[3,2-a]pyrimidine-6-carboxylate

“…[1-3]. The attention of synthetic chemists was drawn to the presence in 4-aryl-3,4-dihydropyrimidine-2-thiones of several reactive nucleophilic centers allowing for a variety of mono-and dialkylation, acylation [4][5][6], and also the very prospective cyclization reaction. For example, the conversion of 4-phenyl-3,4-dihydropyrimidine(1H)-2-thione into 3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine by boiling it in DMF with chloroacetic acid has been described [7].…”