Vegetative status and adaptive capabilities peculiarities of aged 19 to 21 girls depending on their blood circulation self-regulation type were studied in this work. The study was conducted at the Biology Faculty of Zaporizhzhia National University, Zaporizhzhia. Such primary indices as heart rate and blood pressure were studied in all test individuals. Based on the obtained data, the blood circulation self-regulation type in each subject was determined separately, which allowed to form three groups (individuals with cardiovascular, vascular and mixed blood circulation self-regulation types). The assessment scheme included cardiovascular system indices calculation such as average dynamic arterial pressure, specific peripheral resistance, cardiac output, cardiac index, stroke volume, external myocardial function, myocardial stress index, myocardial efficiency criterion, autonomic regulation index (vegetative Kerdo’s index) and adaptive potential. The results were processed by variation statistics methods, and the obtained data were subjected to correlation analysis. Deviations from the reference values were revealed in systemic hemodynamics average group parameters analysis in female students with different blood circulation regulation types. It was recorded that the average dynamic pressure exceeded the normal upper limit by 2.5 % and 6.2 %, respectively, in persons with mixed and vascular regulation type. Specific peripheral resistance indices obtained from data analysis in girls with different blood circulation self-regulation types revealed that this index did not exceed the normal in the groups with mixed and vascular type, in contrast to the group with the cardiac type. The specific peripheral resistance was lower by 5.2 % than the lower limit of the reference value for this index in the latter group. Statistically significant differences were identified in cardiac output, cardiac index and stroke volume parameters in girls with different self-regulation circulatory types. Specific trends were identified in the average group and individual myocardial function indices in girls depending on the self-regulation type. Statistical significance was found between myocardial stress indices in girls with different self-regulation types. Both the average group and individual vegetative Kerdo’s index indices fluctuated within eytony in the mixed type persons group. The mean group autonomic index values in girls with vascular type indicated pronounced vagotonia. We found that the largest percentage of all respondents had satisfactory adaptation. The largest number of girls with satisfactory adaptation had a vascular self-regulation type (83.33 %) and a mixed type (81.82 %), a smaller percentage of girls from these groups (16.68 % and 18.18 %, respectively) had adaptation mechanisms functional stress. In the group with the cardiac type, almost half (46.15 %) had adaptation mechanisms functional stress, and the rest (53.85 %) had satisfactory adaptation. Thus, the differences in cardiovascular system indices, the autonomic nervous system sympathetic and parasympathetic parts influences ratio on the cardiovascular system were determined, as well as the adaptive potential in 19-21 years old girls can be attributed to blood circulation compensatory-adaptive reactions.