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Abstract

Atherosclerosis is a chronic inflammatory disease that is marked by atheroma and patchy intimal plaques in arteries that cause thickening and hardening of arteries. It is reported that "Origanum majorana L." possess antiulcerogenic, antiproliferative, antioxidant, and anticarcinogenic activities, and it is an important remedy against thromboembolic disease. The present study was designed for the evaluation of the anti-atherosclerotic activity of hydrodistilled volatile oil (OMO) of Origanum majorana L. in high-fat diet-induced atherosclerotic rats. The in vitro studies found that OMO possesses fibrinolytic, thrombolytic, and antiplatelet activity. These activities can play an effective role in the antiatherosclerotic activity of OMO. Atherosclerosis was induced using a highfat diet model in atherosclerotic activity of OMO. Atherosclerosis was induced using a high-fat diet model in histopathological examination of the aorta was determined at the end of the study. OMO significantly showed that the levels of total cholesterol (TC), triglyceride (TG), low-density lipid (LDL), and very low-density lipids (VLDL) levels were also decreased, there is a decrease in the level of liver function enzymes and significant changes in haematological parameters, the inflammatory biomarkers seem negative as compared to the normal group. The result suggested that OMO has fibrinolytic, thrombolytic, and antiplatelet activity; hence it contributed to antiatherosclerosis activity in high-fat diet-induced atherosclerotic rats. INTRODUCTION:Atherosclerosis mainly involves the coronary and caratoid arteries, which remain the leading causes of morbidity and mortality in both men and women of all racial groups, with Coronary Heart Disease (CHD) the leading cause of death worldwide. The disease develops slowly over many years in the intima layer of large and medium-sized arteries 1 .