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Endo, Y; Eto, S; Iino, S; Fujiwara, K; Miyake, Kai; Kanetaka, T; Yamanaka, M; Suzuki, H; Oda, T; Yoshitoshi, Y; Juji, T; Yokochi, Taeko; Miura, T

doi:10.2957/kanzo.10.143

Cited by 6 publications

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Serum alpha-fetoglobulin and primary cancer of the liver in Taiwan

Lin

Chu

Chen

et al. 1972

Cancer

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An alpha‐fetoglobulin was found in the sera of 35 out of 48 patients with histologically proved primary liver cell carcinoma (72.9%). The sera of normal healthy persons, of patients with diseases other than primary liver cell carcinoma, and of patients with cholangiocarcinoma were all negative for alpha‐fetoglobulin. Thirty‐three sera from 11 patients with hepatoma were alpha‐fetoglobulin negative by double well diffusion method, of which 30 were further proved to be alpha‐fetoglobulin positive when reassayed by a more sensitive single well radial diffusion method. This fetoprotein appeared more frequently in female or cirrhotic patients with hepatoma than in male or non‐cirrhotic patients. No obvious correlation between alpha‐fetoglobulin and histologic picture, or liver function study or clinical course of hepatoma was evident. Quantitatively, the alpha‐fetoglobulin varied from one patient to another, and, in the same individual, it increased with the growth of hepatoma. The serum level of alpha‐fetoglobulin was scarcely changed by chemotherapy. However, it would disappear or decrease in titer 1 to 3 weeks after resection of hepatoma‐bearing lobe and keep increasing in titer or reappear if hepatoma recurred or metastasized.

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Serum alpha-fetoglobulin and primary cancer of the liver in Taiwan

Lin

Chu

Chen

et al. 1972

Cancer

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α‐fetoprotein and hepatocarcinogenesis in rats fed 3′‐methyl‐4‐(dimethylamino)azobenzene or n‐2‐fluorenylacetamide

Kitagawa

Yokochi

Sugano

1972

Intl Journal of Cancer

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Serum a-fetoprotein ( u f ) of rats during hepatocarcinogenesis by 3'-methyl-4-(dimethylamino) azobenzene (3'-Me-DAB) or N-2-Fluorenylacetamide ( F AAThe histological aspect of the liver during of af production in liver carcinoma according hepatocarcinogenesis and the established carci-to the type of the carcinogen, and suspected a noma has been known to vary considerably positive correlation between the kind of carcinoaccording to differences in age, sex, strain and gen used and uf production by the developed species of the animals or to the kind or dose of carcinoma in general. Abelev (1968), on the the carcinogen used. Birencwajg et a/. (19676) other hand, reported his impression of a positive found a remarkable difference in the frequency correlation between the degree of malignancy

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Human Alphafetoprotein 1956–1978

Adinolfí

1979

Advances in Human Genetics 9

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Abstract: Content of embryo-specific ƒ¿-globulin in fetal and neonatal sera and sera form adult humans with primary carcinoma of the liver, Vop. Med.

Cited by 6 publications

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Serum alpha-fetoglobulin and primary cancer of the liver in Taiwan

Serum alpha-fetoglobulin and primary cancer of the liver in Taiwan

α‐fetoprotein and hepatocarcinogenesis in rats fed 3′‐methyl‐4‐(dimethylamino)azobenzene or n‐2‐fluorenylacetamide

Human Alphafetoprotein 1956–1978

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