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Abstract

Attempts were made to carry out the laboratory synthesis of non-symmetric mono-, di-and tri-substituted 1, 3, 5triazines by the action of the electron-donating substituent on 2, 4, 6trichloro-1, 3, 5-triazines by aromatic nucleophilic substitution reaction mechanism (S N Ar reaction) by temperature controlled. The introduction of the amino group (-NH-), ether (-O-) and thiol (-S-) Linker Bridge show more promising antibacterial activity. The yield of newly synthesized compounds was quite well, and their structures were confirmed by using IR, 1 H NMR, and Mass spectral data. INTRODUCTION: The chemical compound 1,3,5-triazine, also called s-triazine, it is an organic chemical compound whose chemical structure has a six-membered heterocyclic aromatic ring consisting of three carbon atoms and three nitrogen atoms. It is soluble in most organic solvents and very soluble in water. By using 2, 4, 6-trichloro-1, 3, 5-triazine (Cyanuric chloride), three chlorides can be replaced by amine, alcohol, Sulphur and Grignard reagents 1. All of the s-triazine derivatives that have wide practical applications. 1, 3, 5-Triazine is havingmono, di-or tri-substituted, symmetrical and nonsymmetrical compounds bearing different substituents. In 2, 4, 6-Trichloro-1, 3, 5-triazine the ease of displacement of chlorine atoms by various nucleophiles, in the presence of a hydrochloride acceptor (usually sodium carbonate, bicarbonate), makes this reagent useful for the preparation of mono-, di-and tri-substituted 1, 3, 5-triazines.