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Abstract

Background: Hyperpigmentation (HP) is a common dermatological disease. Indian population presents in a variety of dermatological pigmentation. Effects of Nutrients and metabolites factor are important for skin hyperpigmentation condition. Aims and Objectives: In this study, we aimed to evaluate the status of Haemoglobin, vitamin B12, Ferritin, and TSH levels in people with hyperpigmentation from a different region of Aravalli district Gujarat, India. Materials and Method: A study based retrospective, prospective and Multi-centric study conducted at the dermatological outpatient clinics at Modasa, Vatrak, Ranasanarea of Aravalli district, Gujarat, India. In this, we studied a total of 70 hyperpigmented patients fulfilling with inclusion criteria. Hyperpigmentation patients correlate with serum vitamin B12; Ferritin, CBC, and TSH during a four-year period from June 2015 to May 2019 were included in the study. Those were diagnosed with following various examinations and tests. A detailed examination was performed with respect to skin hyperpigmentation. Clinical and laboratory data compare with normal control. Student t-test used for statistical analysis. Results: A total of 70 HP patients were investigated with age group in between 11 to 40 years (mean age of 26.49 ±10.08). We observed common features were dark skin coloration on face, neck, elbow, knee, surround to eyes, on fingers, etc. HP Patients showed serum Haemoglobin level (Mean ± SD, 11.81 ± 2.414) (P value 0.0016 < 0.005). Patient's showed the vitamin B12 level in the HP group (Mean ± SD, 293.4 ± 137.2). It is non-significant. The serum ferritin level in the HP group (Mean ± SD, 44.04 ± 101.7)(P value 0.0072 < 0.005). TSH level showed below normal [<3.0 miu/ml], 03 [7.69%] showed TSH level above Normal range [0.3 to 5.0 miu/ml] and others 35 [89.74 %] showed in normal range (P > 0.005). Conclusion: Skin Hyperpigmentation due to Nutrients and metabolic factors. Serum level of ferritin and Haemoglobin were a significant role in hyperpigmentation conditions, but vitamin B12 played a non-significant role in hyperpigmentation in north Gujarat.INTRODUCTION: Hyperpigmentation (HP) is a common dermatologic problem that may have a significant impact on the patient's appearance and quality of life 1, 2 .