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Abstract

Pulpitis, or pulp inflammation, is a type of dental disease that is commonly associated with tooth pain symptoms. The immune reaction, characterized by TNF-α biomarkers and leukocyte cells, plays a part in the prevalence of pulpitis. (PMN). The latest innovation in dentistry is nanochitosane, which is derived from red snapper scales and includes calcium and chitin. The nanochitosane found in red snapper fish scales (Lutjanus Sp.) has been shown to decrease tumor necrosis factor (TNF) and pain levels. Twenty-four Sprague Dawley rats were splitted into four groups. Healthy rodents comprised group 1. Rats were used in Group II as a reversible pulpitis model with no material change. Rats were used in Group III as a pulpitis model with calcium hydroxide addition. Group IV included rodents as model pulpitis with red snapper fish scale nanochitosane addition. The inclusion of chitosan therapy reduced leukocyte cells, TNF-levels, and pain significantly in group IV compared to group II without therapy and group III with calcium hydroxide treatment. The results of this study showed that redfish scale nanochitosane can decrease inflammation by lowering TNF-and pain levels.