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Алифирова, В. М.; Жукова, Н. Г.; Жукова, И. А.; Mironova, Yu. S.; Петров, В. А.; Izhboldina, O.; Титова, М.; Латыпова, А. В.; Никитина, М. А.; Dorofeeva, Yu. B.; Saltykova, Irina V.; Tyakht, Alexander V.; Kostryukova, Elena S.; Сазонов, А. Э.

doi:10.15690/vramn734

Cited by 2 publications

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“…99,100 Disturbances in the composition of the gut microbiome are closely associated with delayed colonic transit, olfactory dysfunction, emotionalaffective disorders, and depression. 41,101,102 Multiple sclerosis is a chronic autoimmune neurodegenerative disease in which the myelin sheath of nerve fibers in the brain and spinal cord is affected. 103 At certain stages, the mechanisms of neurodegeneration in multiple sclerosis and Alzheimer's disease may have common features.…”

Section: Oxidative Stress and Inflammation In The Formation Of Neurodegenerative Diseasesmentioning

confidence: 99%

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Даниленко¹,

Devyatkin²,

Марсова³

et al. 2021

JIR

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In the last decade, metagenomic studies have shown the key role of the gut microbiome in maintaining immune and neuroendocrine systems. Malfunction of the gut microbiome can induce inflammatory processes, oxidative stress, and cytokine storm. Dysfunction of the gut microbiome can be caused by short-term (virus infection and other infectious diseases) or long-term (environment, nutrition, and stress) factors. Here, we reviewed the inflammation and oxidative stress in neurodegenerative diseases and coronavirus infection (COVID-19). Here, we reviewed the renin-angiotensin-aldosterone system (RAAS) involved in the processes of formation of oxidative stress and inflammation in viral and neurodegenerative diseases. Moreover, the coronavirus uses ACE2 receptors of the RAAS to penetrate human cells. The coronavirus infection can be the trigger for neurodegenerative diseases by dysfunction of the RAAS. Pharmabiotics, postbiotics, and nextgeneration probiotics, are considered as a means to prevent oxidative stress, inflammatory processes, neurodegenerative and viral diseases through gut microbiome regulation.

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Section: Oxidative Stress and Inflammation In The Formation Of Neurodegenerative Diseasesmentioning

confidence: 99%

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Даниленко¹,

Devyatkin²,

Марсова³

et al. 2021

JIR

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The Gut and Parkinson’s Disease: Hype or Hope?

Scheperjans

Derkinderen

Borghammer

2018

Journal of Parkinson’s Disease

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In the last two decades it has become clear that Parkinson’s disease (PD) is associated with a plethora of gastrointestinal symptoms originating from functional and structural changes in the gut and its associated neural structures. This is of particular interest not only because such symptoms have a major impact on the quality of life of PD patients, but also since accumulating evidence suggests that in at least a subgroup of patients, these disturbances precede the motor symptoms and diagnosis of PD by years and may thus give important insights into the origin and pathogenesis of the disease. In this mini-review we attempt to concisely summarize the current knowledge after two decades of research on the gut-brain axis in PD. We focus on alpha-synuclein pathology, biomarkers, and the gut microbiota and envision the development and impact of these research areas for the two decades to come.

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Abstract: The data we received in our study allow better understanding of PD pathogenesis.

Cited by 2 publications

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Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

The Gut and Parkinson’s Disease: Hype or Hope?

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