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Zadymova, N. M.; Tsikurina, N. N.; Poteshnova, M. V.

doi:10.1023/a:1024202705763

Cited by 12 publications

(3 citation statements)

References 4 publications

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“…According to the laws of colloidal chemistry, the strength of the surface-active adsorption layer (adlayer) is provided by good adhesion of emulsifier molecules to the fluorocarbon phase. PFCs used for the creation of medico-biological emulsions are virtually insoluble in water [1,2] and poorly dissolve other compounds [3]. For this reason, the particles in PFC emulsions possess a double-layer spherical structure [4].…”

mentioning

confidence: 99%

Structural stability of perfluorocarbon and phospholipid emulsions on storage

Кузнецова

Yurchenko

2006

Pharm Chem J

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Stability of perfluorocarbon (PFC) emulsions with natural phospholipids as surfactants has been studied under conditions of long-term storage without freezing. Changes in the structure of emulsions were monitored with respect to the (i) general structure (characterized by the average diameter and the particle size distribution) and (ii) microstructure (characterized by the indices of interaction between PFC emulsion and the blood serum). It was established that the particle size and the structure of PFC emulsions remained almost unchanged during 12-month storage at +4°C. The average particle diameter did not exceed 0.2 mm during the entire period of observations.

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confidence: 99%

Structural stability of perfluorocarbon and phospholipid emulsions on storage

Кузнецова

Yurchenko

2006

Pharm Chem J

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“…The study of quercetin solubilization in antiseptic micelles was carried out according to the classical scheme described in [ 17 ]. A series of 4.0 mL aqueous micellar solutions of miramistin with concentrations of 1, 3, 6, and 9 mM was prepared.…”

Section: Methodsmentioning

confidence: 99%

“…This possibility exists due to the ability of hydrophobic compounds to be solubilized in surfactant micelles. It is known [ 16 , 17 , 18 , 19 ] that micellar solubilization can significantly enhance the water solubility (i.e., bioavailability) of hydrophobic drugs. Moreover, surfactant micelles containing a hydrophobic solubilizate can serve as effective hybrid templates in the synthesis of MSNs [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Bionanocomposites Based on Drug-Templated Bifunctional Mesoporous Silica Nanocontainers

Shishmakova,

Ivchenko,

Bolshakova

et al. 2023

Pharmaceutics

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The creation of antibacterial nanocomposites that provide prolonged release of encapsulated drugs is of great interest for various fields of medicine (dentistry, tissue regeneration, etc.). This article demonstrates the possibility of creating such nanocomposites based on sodium alginate and drug-templated mesoporous silica nanocontainers (MSNs) loaded with two bioactive substances. Herein, we thoroughly study all stages of the process, starting with the synthesis of MSNs using antiseptic micelles containing the hydrophobic drug quercetin and ending with assessing the activity of the resulting composites against various microorganisms. The main emphasis is on studying the quercetin solubilization in antiseptic micelles as well as establishing the relationship between the conditions of MSN synthesis and micelle morphology and capacity. The effect of medium pH on the release rate of encapsulated drugs is also evaluated. It was shown that the MSNs contained large amounts of encapsulated drugs and that the rate of drug unloading depended on the medium pH. The incorporation of such MSNs into the alginate matrix allowed for a prolonged release of the drugs.

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Quantitative and time-course analysis of microbial degradation of 1H,1H,2H,2H,8H,8H–perfluorododecanol in activated sludge

Arakaki

Nakata

Tokuhisa

et al. 2017

Appl Microbiol Biotechnol

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A methylene group in the fluorinated carbon backbone of 1H,1H,2H,2H,8H,8H-perfluorododecanol (degradable telomer fluoroalcohol, DTFA) renders the molecule cleavable by microbial degradation into two fluorinated carboxylic acids. Several biodegradation products of DTFA are known, but their rates of conversion and fates in the environment have not been determined. We used liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) to quantitatively investigate DTFA biodegradation by the microbial community in activated sludge in polyethylene terephthalate (PET) flasks, which we also determined here showed least adsorption of DTFA. A reduction in DTFA concentration in the medium was accompanied by rapid increases in the concentrations of 2H,2H,8H,8H-perfluorododecanoic acid (2H,2H,8H,8H-PFDoA), 2H,8H,8H-2-perfluorododecenoic acid (2H,8H,8H-2-PFUDoA), and 2H,2H,8H-7-perfluorododecenoic acid and 2H,2H,8H-8-perfluorododecenoic acid (2H,2H,8H-7-PFUDoA/2H,2H,8H-8-PFUDoA), which were in turn followed by an increase in 6H,6H-perfluorodecanoic acid (6H,6H-PFDeA) concentration, and decreases in 2H,2H,8H,8H-PFDoA, 2H,8H,8H-2-PFUDoA, and 2H,2H,8H-7-PFUDoA/2H,2H,8H-8-PFUDoA concentrations. Accumulation of perfluorobutanoic acid (PFBA), a presumed end product of DTFA degradation, was also detected. Our quantitative and time-course study of the concentrations of these compounds reveals main routes of DTFA biodegradation, and the presence of new biodegradation pathways.

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Cited by 12 publications

References 4 publications

Structural stability of perfluorocarbon and phospholipid emulsions on storage

Structural stability of perfluorocarbon and phospholipid emulsions on storage

Antibacterial Bionanocomposites Based on Drug-Templated Bifunctional Mesoporous Silica Nanocontainers

Quantitative and time-course analysis of microbial degradation of 1H,1H,2H,2H,8H,8H–perfluorododecanol in activated sludge

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