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Abstract

Aim:The present study aimed to develop and demonstrate the study of combined effects of biodegradable polymer coated with different pH-sensitive polymers in the formulation of Metronidazole tablets for colon targeted drug delivery. Materials and Methods: Metronidazole Hydrochloride is cored with various proportions of biodegradable polymers such as xanthan gum and chitosan. Then, the double-layered system was designed based on pH-sensitive eudragit S100 and eudragit L100 as an inner layer and outer layer, respectively. To evaluate the in-vitro dissolution profile of CODES TM tablets in gastrointestinal fluids, the test was performed using three consecutive media and drug release kinetics are performed. The drug excipient interaction of CODES TM formulation was characterized by Fourier transform infrared (FT-IR). Results and Discussion: From the in-vitro drug release studies, F6 tablets were considered as the optimized formulation, which retard the drug release in the stomach (pH 1.2) and small intestine (pH 7.4) and progressively increase the release of 75.75% in the colon (pH 6.8) due to mucoadhesive properties of chitosan. The FT-IR analysis shows that there is no interaction between drug and excipient. The drug release kinetics followed supercase -II transport with erosion mechanism. Conclusion: Briefly to conclude that CODES TM technology is a promising method for approach to deliver drug to colon due to the controlled release of biodegradable polysaccharides and gastric resistance polymer.