Untitled

Abstract

A series of novel (Z)-3-((5-(2-((E)-arylidene) hydrazine-1carbonyl)-4-methylthiazol-2-yl)amino)-2-cyano-3-(methylthio) acrylate 4a-t molecules have been synthesized and characterized by 1 H NMR, 13 C NMRand mass spectral analysis. Starting from ethyl 2-amino-4methylthiazole-5-carboxylate 1 was reacted with hydrazine hydrate to obtain carbohydrazide molecule 2. Furthermore, reaction of molecule 2 with various aldehyde and the adduct 3a-t formed was reacted with ethyl 2-cyano-3,3-bis(methylthio) acrylate to get novel thiazole derivatives 4at, furthermore it was reacted with lithium hydroxide to form acid containing novel thiazole molecule 5a. The significant features of this reaction procedure are novel, easy and less time consuming with analytically pure product formation. INTRODUCTION:Thiazole moiety is present in several medicinal compounds and natural sources. The first widely used antibiotic penicillin, also have thiazole moiety in its core structure. Numerous medicinal drugs available for various types of illness also hold thiazole moiety, as shown in Fig. 1. Thiazoles and their derivatives also play a significant role in the field of medicinal chemistry where they found to exhibit a wide variety of activities such as, antiviral 1 , antioxidant 2 , antituberculosis 3 , antimicrobial 4 , anticancer 5 , anticonvulsant 6 , anti-inflammatory 7 , anti-infective 8 , antidiabetic 9 , anticonvulsant 10 , antifungal 11 , antiepileptic 12 , antidepressant 13 . Some of the thiazole molecules also showed inhibition against SARS-CoV-2 virus disease 14,15 . Several procedures for synthesizing thiazole derivatives are described in the literature [16][17][18][19][20][21][22][23] .