Untitled

Abstract

The main objective of the present study was to develop and evaluate the simvastatin noisome using different grades of nonionic surfactants. It was hypothesized that niosomes would increase in vitro release of simvastatin in comparison to the API Mumbai. Niosome were prepared by thin-film hydration method and evaluated for particle size, entrapment efficiency, PDI, and in vitro release. The different niosomes shows various mean particle size, but Span 60 containing Niosomes have higher particle size than Span 80. Both optimized formulations of Span 60 and Span 80 have particle size 225.40 and 261.4. The PDI, entrapment efficiency of these optimized formulations was found to be 0.153, 0.167 and 85.72 ± 2.10, 81.44 ± 3.83, respectively. Niosomes prolonged the release of Simvastatin and provided a sustained release pattern. From the current study, it may be concluded that formulation F2 containing 2:1 (Span 60: Cholesterol) and F8 containing 1:3 (Span 60: Cholesterol) were found to be high % of entrapment efficiency and desired sustained release of simvastatin. Span 60 is a better non-ionic surfactant for preparation of noisome in comparison to Span 80, and niosomal drug delivery system of simvastatin is a simple and effective approach to produce nanoparticles of poorly water-soluble drug to enhance the release. These niosomes will probably reduce the frequency of administration of Simvastatin.

Placenta Extract-Loaded Novasome Significantly Improved Hair Growth in a Rat in Vivo Model

“…This result was in agreement with those obtained by Diksha et al [24]. It might be because span 60 has higher Tc (53 °C) than span 80 (-12 °C), thus providing higher %EE [12].…”