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Nishino, Hoyoku; Murakoshi, Michiaki; Tsunehiro,; Takemura, Manabu; Kuchide, Masashi; Kanazawa, M.; Mou, Xiao; Wada, Saeri; Masuda, Michiaki; Ohsaka, Yasuhito; Yogosawa, Shingo; Satomi, Yoshiko; Jinno, Kenji

doi:10.1023/a:1021206826750

Cited by 185 publications

(54 citation statements)

References 10 publications

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“…[28][29][30] In this study, we demonstrated that the chronic intake of b-CRX and mandarin, in which b-CRX was the main carotenoid, prevented the decrease in learning ability and the increase in DNA oxidative damage in the cerebral cortex of aged SAMP10 mice (Figs. 3, 4).…”

Section: Discussionmentioning

confidence: 62%

Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-Related Cognitive Dysfunction and Oxidative Damage in Senescence-Accelerated Mouse Brain

Unno

Sugiura

Ogawa

et al. 2011

Biological & Pharmaceutical Bulletin

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The brain is highly susceptible to oxidative damage because it consumes a large amount of oxygen and generates many free radicals as normal products of cellular metabolism. [1][2][3] In addition, the brain contains diverse lipid components and fewer antioxidant enzymes than other organs. 4) Although the antioxidant defense system responds to an increase in the production of reactive oxygen species (ROS) or peroxide under normal conditions, it gives rise to oxidative stress in the brain if an imbalance occurs between the production of ROS and the cellular defense capability. Aging is an important risk factor of this imbalance. Accumulation of oxidative damage is the most probable cause of the decline in learning and memory with aging.5) Preventing the accumulation of ROS-causing oxidative damage might suppress cognitive dysfunction.Several studies have demonstrated that dietary antioxidants from fruits and vegetables prevent oxidative stress in the brain.6-10) Neuroprotective dietary compounds have an essential role in reducing aging of the brain.11,12) Beta-cryptoxanthin (b-CRX, (3R)-b,b-caroten-3-ol, Fig. 1) is the main precursor of vitamin A in citrus juices.13) This carotenoid is not fully cleaved in vitamin A in the gut and it is therefore recovered in human plasma.14) Recent clinical studies indicated that the frequent intake of citrus fruits increases plasma b-CRX concentrations and reported b-CRX to be a biomarker of mandarin consumption.15) The concentrations of carotenoids, tocopherols and retinols were investigated in an aged human brain.16) An age-related decline in retinol, total tocopherols, total xanthophylls (oxygenated carotenoids) and total carotenoids was observed in frontal but not in occipital lobes. The antioxidative activity of b-CRX has been reported to scavenge radicals, 17) and to suppress lipid peroxidation 18) and nitrogen oxide production.19) The important role of antioxidants in the brain is thus expected. In this study, we investigated the effect of consumption of b-CRX (Fig. 1) and Satsuma mandarin orange (mandarin, Citrus unshiu MARC.) juice on brain function because b-CRX is rich in mandarin, the most popular fruit in Japan.We investigated the effect of b-CRX and mandarin juice on the brain using senescence-prone mouse strain 10 (SAMP10), which is a useful model of brain aging with a short life span and declined learning ability in later life. 20,21) Moreover, the production of superoxide anion was higher in SAMP10 than in other mice with normal longevity and brain function. 22) In addition, our previous data indicates that the consumption of green tea catechin (catechin), a potent antioxidant in green tea, suppressed brain dysfunction and DNA oxidative damage in aged SAMP10. [23][24][25] These data strongly suggest that chronic intake of other antioxidants in fruits and vegetables also play a role in reducing the risk of age-related brain dysfunction. In this study, we investigated the effect of chronic consumption of b-CRX and mandarin juice, which contains a similar amount of ...

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Section: Discussionmentioning

confidence: 62%

Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-Related Cognitive Dysfunction and Oxidative Damage in Senescence-Accelerated Mouse Brain

Unno

Sugiura

Ogawa

et al. 2011

Biological & Pharmaceutical Bulletin

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“…The production of phytoene led by the transgenic cells led to protection against oxidative stress (assessed by measuring phospholipid peroxidation induced by oxidative stress) and malignant transformation. The authors stated that the term ''bio-chemoprevention'' (''biotechnology-assisted method for cancer chemoprevention'') may be applicable in this context as the transgenic cells acquired resistance against carcinogenesis [141].…”

Section: Breast and Endometrial Cancermentioning

confidence: 99%

A comprehensive review on the colorless carotenoids phytoene and phytofluene

Meléndez-Martínez

Benítez-González

Stinco

2015

Archives of Biochemistry and Biophysics

154

112

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“…They have an important antioxidant function of scavenging singlet molecular oxygen and peroxyl radicals [7]. Although whether carotenoids are beneficial to human health is disputable [8], observational studies have proposed that dietary carotenoid intake or circulating carotenoid serum levels are associated with a reduced risk of mortality [9,10], cardiovascular diseases [11,12], cancer [13,14], stroke [15], and other conditions [16]. However, there is little evidence of an association between carotenoids and AD involving oxidative stress mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer's Disease Mortality in Older Adults

Min

2013

Dement Geriatr Cogn Disord

114

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Background: Oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD). Accumulating evidence shows that antioxidant-rich food reduces the risk of AD by inhibiting oxidative stress. This study investigates whether serum levels of carotenoids were associated with the risk of AD mortality in a nationally representative sample of US adults. Methods: We used data from the Third Nutrition and Health Examination Survey (NHANES III) database and the NHANES III Linked Mortality File. A total of 6,958 participants aged older than 50 years were included in this study. Results: We found that high serum levels of lycopene and lutein+zeaxanthin at baseline were associated with a lower risk of AD mortality after adjustment for potential covariates. The reduction in the mortality risk was progressively raised by increasing serum lycopene (HR = 0.26, 95% CI 0.10-0.69) and lutein+zeaxanthin (HR = 0.43, 95% CI 0.22-0.85) levels. In contrast, no associations with AD mortality were observed for other serum carotenoids, including alpha-carotene, beta-carotene, and beta-cryptoxanthin. Conclusion: High serum levels of lycopene and lutein+zeaxanthin are associated with a lower risk of AD mortality in adults. Our findings suggest that a high intake of lycopene- or lutein+zeaxanthin-rich food may be important for reducing the AD mortality risk.

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Cited by 185 publications

References 10 publications

Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-Related Cognitive Dysfunction and Oxidative Damage in Senescence-Accelerated Mouse Brain

Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-Related Cognitive Dysfunction and Oxidative Damage in Senescence-Accelerated Mouse Brain

A comprehensive review on the colorless carotenoids phytoene and phytofluene

Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer's Disease Mortality in Older Adults

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