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Güllüoğlu, Bahadır M.; Bekraki, A; Çerıkçıoğlu, Nilgũn; Sõyletır, Gũner; Aktan, A. Özdemir

doi:10.1023/a:1012399114305

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Notably, hyperthermia preconditioning has been demonstrated to be an effective method to protect against OJ-induced liver injury in rats (9). The results from this study were in accordance with previous studies, which demonstrated that hyperthermic preconditioning enhances the immune response of rats with OJ (10,11). …”

Section: Introductionsupporting

confidence: 93%

Histone preconditioning protects against obstructive jaundice-induced liver injury in rats

Zhou¹,

Ni²,

Liu³

et al. 2014

Experimental and Therapeutic Medicine

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A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs from injury, and histones have been recently identified as DAMP molecules. The aim of the present study was to investigate the protective effect of histone preconditioning against OJ-induced liver injury in rats and the involvement of Toll-like receptors. Rats were administered histone proteins (200 μg/kg; 1 ml) or physiological saline (1 ml) intraperitoneally 24 h prior to being subjected to bile duct ligation (BDL). The serum levels of liver enzymes and bilirubin, as well as the histopathology were analyzed. The mRNA expression of interleukin-6 (IL-6) in the liver tissue was analyzed using quantitative polymerase chain reaction. BDL in the control group caused severe OJ-induced liver injury, as indicated by the significantly elevated levels of liver enzymes and mRNA levels of IL-6, and confirmed by histopathological alterations. However, histone preconditioning significantly ameliorated the OJ-induced liver injury caused by BDL, as shown by an improvement in the levels of liver enzymes, a suppression of IL-6 production, as well as histopathological alterations. Therefore, these results suggested that histone preconditioning is able to protect against OJ-induced liver injury in rats.

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Section: Introductionsupporting

confidence: 93%

Histone preconditioning protects against obstructive jaundice-induced liver injury in rats

Zhou¹,

Ni²,

Liu³

et al. 2014

Experimental and Therapeutic Medicine

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“…This improvement suggests an enhancement in the body's immune function to some extent. Additionally, there is evidence demonstrating that exposing lymphokine-activated killer cells to temperatures above 45 degrees Celsius significantly enhances their tumor-killing activity 20 . Furthermore, this temperature exposure also enhances the immune effects of macrophages, lymphocytes, and other cells 21 .…”

Section: Discussionmentioning

confidence: 99%

Effect of hyperthermia on intestinal microecology, immune function, and progression-free survival in patients with advanced unresectable lung adenocarcinoma

Tian,

Long,

Zang

et al. 2023

Sci Rep

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This study aims to investigate the effects of hyperthermia on intestinal microecology, immune function, and progression-free survival of patients with advanced unresectable lung adenocarcinoma. A total of twenty patients with lung adenocarcinoma in the study group received the advanced standard first-line treatment protocol, which included pemetrexed + cisplatin combined with sintilimab immunotherapy and hyperthermia. Additionally, twenty patients with lung adenocarcinoma in the control group received the advanced standard first-line treatment protocol, which included pemetrexed + cisplatin combined with sintilimab immunotherapy. The T-lymphocyte subpopulation and CD4/CD8 cell ratio of each sample were detected using flow cytometry. The intestinal flora was evaluated using 16S rRNA gene sequencing. The study observed the changes in the abundance, distribution, composition, and structure of fecal gut microorganisms before and after the treatment in both groups of patients. Significant differences were observed in the intestinal flora between the two groups. The patients in the study group showed improved immunity after treatment, whereas there was no significant change in the immunity of the control group before and after treatment. However, the difference in progression-free survival between the two groups was not statistically significant. Hyperthermia has a significant impact on improving the microecology of intestinal flora and the immunity of patients, but it does not have a significant effect on prolonging the progression-free survival of patients.

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Dissecting the role of hyperthermia in natural killer cell mediated anti-tumor responses

Dayanç

Beachy

Ostberg

et al. 2008

International Journal of Hyperthermia

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The effects of hyperthermia on natural killer (NK) cell cytotoxicity against tumor cell targets are not yet fully understood. A more complete understanding of these effects could be important for maximizing the clinical benefits obtained by using hyperthermia for cancer therapy. Here, we summarize results in the literature regarding the effects of elevated temperatures on NK cells and our own recent data on the effects of fever-range temperatures. At treatment temperatures above 40 degrees C, (which is above the physiological body temperatures normally achieved during fever or exercise), both enhancing and inhibitory effects on cytotoxic activity of NK cells against tumor cells have been reported. Our own results have shown that fever-range thermal stress (using a temperature of 39.5 degrees C) enhances human NK cell cytotoxicity against tumor target cells. This effect requires function of the NKG2D receptor of NK cells, and is maximal when both NK and tumor cell targets are heated. Reported heat sensitive cellular targets affected by hyperthermia on tumor cells include heat shock proteins, MICA and MHC Class I. In NK cells, plasma membrane reorganization may occur after mild heat stress. We conclude this review by listing several unresolved questions that should be addressed for a more complete understanding of the molecular mechanisms which underlie the effects of thermal stress on the function of NK cells. Altogether, the available data indicate a strong potential for heat-induced enhancement of NK cell activity in mediating, at least in part, the improved clinical responses seen when hyperthermia is used in combination with other therapies.

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Untitled

Cited by 6 publications

References 15 publications

Histone preconditioning protects against obstructive jaundice-induced liver injury in rats

Histone preconditioning protects against obstructive jaundice-induced liver injury in rats

Effect of hyperthermia on intestinal microecology, immune function, and progression-free survival in patients with advanced unresectable lung adenocarcinoma

Dissecting the role of hyperthermia in natural killer cell mediated anti-tumor responses

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