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Efficient removal of uranium from the kidneys by a picolinate-based pentadentate chelator

“…However, accidental uranium intake can lead to its accumulation in target organs, causing renal damage and osteosarcoma, as well as other health concerns. [1][2][3] Currently, chelation therapy is considered the most effective treatment for radionuclide poisoning. 4 To be specific, this therapy employs decorporation agents to bind metal ions, forming stable complexes and facilitating their excretion, thereby reducing the radiation damage and chemical toxicity arising from the retention of radionuclides in vivo.…”