Untitled

Abstract

The objective of the present study is to develop, evaluate and compare potent phytoconstituents of curcumin loaded solid lipid nanoparticles (CUR-SLN) and Paclitaxel loaded solid lipid nanoparticles (PTX-SLN) for the treatment of malignancy. Curcumin is an active phenolic compound of Curcuma longa as a promising phytoconstituent has been extensively studied over the past several years. The result of these studies has indicated that the curcumin (CUR) acts on multiple molecular targets to selectively kill tumor cells with low intrinsic toxicity. The well-known anticancer agent Paclitaxel (PTX) is used for its effectiveness in the treatment of a wide range of tumors cells. However, due to the hydrophobic nature of PTX limits its effective application as anticancer drug. This study utilizes the immense potential of nanotechnology, particularly SLNs, in improving safety & bioavailability of CUR and PTX. SLN was chosen due to their excellent lipoidal drug carrier properties, physiological compatibility, and economic standpoint. In this study physical mixture of CUR-SLN and PTX-SLN formulation and PTX-SLN formulation were examined on Ehrlich ascites carcinoma (EAC) cells for anticancer study. It was observed that the physical mixture of CUR-PTX and PTX-SLN was more effective than PTX-SLN.A great deal of attention has been paid to delivery systems based on highly biocompatible and biodegradable components such as lipids and phospholipids. As a result, different types of nanocarriers such as SLN and nanostructured lipid carriers (NLC) have been developed 4 . SLN and NLC were designed as exceptionally safe colloidal carriers for the delivery of poorly soluble drugs. SLN/NLC has the particularity of being composed of excipients already approved for use in medicines for human use, which offers a great advantage over any other nanoparticulate system developed from novel materials 5 . SLNs were reported as an alternative drug delivery system to traditional polymeric nanoparticles. SLN for controlled release drug delivery-drug release and release mechanism.