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Abstract

Consistently the preparation of transition metal complexes of βdiketones has been (and it still is) an area of the highest interest for inorganic and organic chemists, as can be inferred considering the quantity and diversity of research developed in this field. 1,3-Diketones are wide range of valuable molecules including several types of carbocycles and heterocycles hence have high interest. In fact, excessive amount of therapeutical uses are associated with these 1,3-Diketone compounds. The present work is based mainly on the ultrasound irradiation synthesis of various β-diketone ligands and their Fe (III) complexes. At ambient temperature, the clinically active and functionalized various β-diketones has been synthesized from Baker-Venkataraman transformation and its Fe (III) complexes has been prepared and characterized by physical, spectral and analytical data. The different spectroscopic analysis like Mass, 1 H-NMR, 13 C-NMR, IR, UV and elemental analysis were done. The functionalized beta-diketones showed a certain behaviour and behaved as bidentate ligand and co-ordinate with the transition metal atom through betadiketo system. The complexes have general formula [ML 2 ]. The biological activities like antibacterial and antifungal were performed for the synthesized compounds. The biological screening data indicated that the transition metal complexes are more potent antibacterial, antifungal and antioxidant agents than the parent functionalized beta diketones against different species of bacteria and fungi. This constitutes a new group of compounds. The thermal stability of the newly synthesized metal complexes has been studied. INTRODUCTION:For almost a century the chemistry of 1,3-diketones has attracted the attention of scientists. Diketones are the key intermediates for the synthesis of heterocycles such as isoxazole 1 , flavones 2 , pyrimidine 3 , triazole 4 , pyrazole [5] and benzodiazepines 6 . β-diketone for eg. Anabena β-diketone hydrolase have some QUICK RESPONSE CODE