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Abstract

The PI3K-AKT-mTOR signaling pathway is widely used in cancer therapy as it is a signaling pathway that is frequently disrupted in human cancers. Increasingly, inhibitors develop against key proteins in signaling pathways, such as PI3K and mTOR. Dual inhibitors targeting PI3K and mTOR are more potent than one inhibitor targeting only a single protein. This study used to design and molecular docking analysis to investigate the precise binding positions and interaction forces of quinoxaline-containing compounds within the active site of PI3Kγ and mTOR with the help of freely available software for virtual screening of compounds, docking, and drug interaction result analysis. And also proposed the development of new potent drug candidates which works as dual inhibitors against cancer diseases; thus it could be concluded that Quinoxaline-containing derivatives might be used as a template for destiny improvement thru change or derivatization to lay out stronger healing agents. INTRODUCTION:Cancer is an epidemic worldwide, a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. The most common cancers are breast, lung, colon, rectum, and prostate cancers 1 . With the worldwide devastation the sickness is wreaking, the call for brand-new and powerful drugs is inexhaustible. The position of the PI3K-AKT-mTOR signaling pathway is an essential boom signaling pathway, advancing our knowledge that its ongoing activation in numerous cancers kinds is rising as a fascinating goal for most cancers therapy 2-5 .