Untitled

Ajello, Francesca; Licata, R La; Lodato, M.; Vitale, Francesco; Bonura, Francesca; Valenti, Rosalia Maria; Bruno, M.; Romano, Nino

doi:10.1023/a:1007632617516

Cited by 4 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…sTNF-RI and sTNF-RII levels did not differ between IRs and INRs. Levels of sTNF-RII were higher in INRs than in UCs, and were more comparable to those observed in viremic subjects (121).…”

Section: Otherssupporting

confidence: 60%

Alterations in circulating markers in HIV/AIDS patients with poor immune reconstitution: Novel insights from microbial translocation and innate immunity

Xiao

Yu²,

Yan³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

After long-term anti-retroviral therapy (ART) treatment, most human immunodeficiency virus (HIV)/Acquired Immure Deficiency Syndrome (AIDS) patients can achieve virological suppression and gradual recovery of CD4+ T-lymphocyte (CD4+ T cell) counts. However, some patients still fail to attain normal CD4+ T cell counts; this group of patients are called immune non-responders (INRs), and these patients show severe immune dysfunction. The potential mechanism of poor immune reconstitution (PIR) remains unclear and the identification of uniform biomarkers to predict the occurrence of PIR is particularly vital. But limited information is available on the relationship between circulating markers of INRs and immune recovery. Hence, this review summarises alterations in the intestine microbiota and associated markers in the setting of PIR to better understand host-microbiota-metabolite interactions in HIV immune reconstitution and to identify biomarkers that can predict recovery of CD4+ T cell counts in INRs.

show abstract

“…sTNF-RI and sTNF-RII levels did not differ between IRs and INRs. Levels of sTNF-RII were higher in INRs than in UCs, and were more comparable to those observed in viremic subjects (121).…”

Section: Otherssupporting

confidence: 60%

Alterations in circulating markers in HIV/AIDS patients with poor immune reconstitution: Novel insights from microbial translocation and innate immunity

Xiao

Yu²,

Yan³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…After screening citation data and abstracts, the full-text version of 182 reports (6.8%) were assessed by both M-JSM and BDM. Of these, 56 (2.1%) are included in this report [20–77]. Figure 1 presents the results of the acquisition, screening and selection process.…”

Section: Resultsmentioning

confidence: 99%

“…Survival of HIV-seropositive IDU was investigated in 23 studies, in which 11 (20%) [20, 22, 26, 27, 37, 48, 53, 57, 67, 68, 70] modeled all-cause mortality, 6 (11%) [24, 34, 39, 59, 62, 72] modeled HIV- or AIDS-related mortality, 2 (4%) [58, 73] modeled infectious disease-related mortality and 3 (5%) [63, 64, 71] modeled time to pre-AIDS mortality. Unsurprisingly, both HIV-related and all-cause mortality rates were high in studies of untreated IDU populations, approximating 50 per 1000 person-years [24, 27, 42, 53, 59, 62, 63, 72, 73].…”

Section: Resultsmentioning

confidence: 99%

“…Unsurprisingly, both HIV-related and all-cause mortality rates were high in studies of untreated IDU populations, approximating 50 per 1000 person-years [24, 27, 42, 53, 59, 62, 63, 72, 73]. Studies among HAART-naïve samples [20, 24, 26, 27, 37, 39, 53, 58, 59, 62–64, 67, 68, 73] found little evidence of unique clinical or biological correlates of survival among IDU. As with analyses of time to AIDS, studies of the relationship between patterns of illicit drug use and HIV-related death were contradictory.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Social and structural factors associated with HIV disease progression among illicit drug users

Milloy

Marshall

Kerr

et al. 2012

Aids

View full text Add to dashboard Cite

Objective To systematically review factors associated with HIV disease progression among illicit drug users, focusing on exposures exogenous to individuals that likely shape access and adherence to HIV treatment. Design A systematic review of peer-reviewed English-language studies among HIV-seropositive illicit drug users with at least one of these endpoint of interest: a diagnosis of AIDS; death; changes/differences in CD4 cell counts; or changes/differences in plasma HIV-1 RNA levels. Methods Articles were included if they reported factors associated with an outcome of interest among a group of illicit drug users. Studies were identified, screened and selected using systematic methods. Results Of 2,668 studies matching the search criteria, 58 (2%) met the inclusion criteria, all but one from North America or Western Europe. Overall, 41 (71%) studies contained significant individual-level clinical characteristics or behaviours (e.g., illicit drug use) associated with disease progression. Fifteen studies (26%) identified significant social, physical, economic or policy-level exposures, including incarceration, housing status or lack of legal income. Conclusion While past studies demonstrate important environmental exposures that appear to shape access to care and subsequent disease progression, the limited literature to examine these factors demonstrates the need for future research to consider risk environment characteristics and the role they may play in shaping health outcomes from HIV infection among drug users through determining access and adherence to evidence-based care. (198 words)

show abstract

Associations of Circulating Soluble Tumor Necrosis Factor-α Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection

Leng

Dandorf

et al. 2015

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

Chronic inflammation marked by elevated interleukin (IL)-6, soluble tumor necrosis factor (TNF)-α receptor (sTNFR)-1, and sTNFR-2 levels may play a detrimental role in aging and HIV infection. This study aimed to evaluate the relationships of circulating IL-6 with sTNFR-1 and sTNFR-2 levels in an aging cohort of injection drug users (IDUs) with or at high risk for HIV infection. The AIDS Linked to the Intravenous Experience (ALIVE) study is a community-recruited, prospective observational study of former and current IDUs in Baltimore, Maryland. Serum IL-6, sTNFR-1, and sTNFR-2 levels were measured using standard ELISA. Multivariate linear regression analysis was employed, adjusting for age, sex, HIV status, injection drug use, comorbidities, as well as HIV viral load, CD4 T cell counts, and antiretroviral therapy where appropriate. The analysis included 1,178 participants (316 HIV positive and 862 HIV negative). In the adjusted model, sTNFR-1 and sTNFR-2 were individually associated with IL-6 (regression coefficient: 0.877 and 0.556, respectively, for all participants; 0.607 and 0.407 for HIV positives; and 0.999 and 0.628 for HIV negatives, all p < 0.0001). In the model combining sTNFR-1 and sTNFR-2, the associations for sTNFR-1 remained significant (0.693 for all participants, p < 0.0001; 0.417 for HIV positives, p < 0.05; and 0.840 for HIV negatives), while those for sTNFR-2 were no longer significant. sTNFR-1 and sTNFR-2 were positively associated with IL-6 in ALIVE participants. These findings provide initial insight into the in vivo relationship between TNF-α activation and IL-6 and a basis for further investigations into potential mechanisms underlying chronic inflammation in aging and HIV infection.

show abstract

Untitled

Abstract: sTNFRs concentration is higher in IVDUs than in healthy controls and is highest in AIDS patients. Survival of patients with AIDS is associated with variation in the concentration of sTNFR-II.

Cited by 4 publications

References 47 publications

Alterations in circulating markers in HIV/AIDS patients with poor immune reconstitution: Novel insights from microbial translocation and innate immunity

Alterations in circulating markers in HIV/AIDS patients with poor immune reconstitution: Novel insights from microbial translocation and innate immunity

Social and structural factors associated with HIV disease progression among illicit drug users

Associations of Circulating Soluble Tumor Necrosis Factor-α Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection

Contact Info

Product

Resources

About