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Abstract

Isatin (1H-indole-2,3-dione) and its derivatives represent an important class of heterocyclic compounds that can be used as precursors for drug production. Erdmann1 and Laurent2 first discovered isatin in 1840 as an oxidation product of indigo dye for nitric acid and chromic acid. Isatin is one of the most important heterocyclic compounds. For example, Schiff foundations of isatin are used for their medicinal properties. This review understands a variety of synthetic methods in particular, sandmeyer synthesis, stolle synthesis, and gassman synthesis isatin synthesis. This review reports some of the biological applications of Isatin derivatives such as anticancer, antiviral, antifungal, antioxidant, etc. From these studies, Isatin was established as a promising candidate for further research and investigation in a number of fields. INTRODUCTION:Tribulin was the first name given to Isatin. 1-Hindole-2, 3-Dione is the chemical name for isatin, from which the indole comes. Erdman and Laurent began making this ingredient in 1841 by adding Indigo dye for chromic acid and nitric acid. The compound is found in many plants, such as Isatis tinctoria, Calanthe discolor, and Couroupita guianensis. Isatin is also found in plants, such as melosatin alkaloids (methoxy phenylpentyl isatins) in Melochia tomentosa. Isatin is also found in humans as a metabolic effect of adrenaline 1 .