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Keerthi, D. Shruthi

doi:10.22377/ajp.v11i01.1099

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…22 In the second step, acetanilide was added to chlorosulfonic acid and stirred at room temperature to generate 4-acetamidobenzene-1-sulfonyl chloride. 23 Finally, the newly synthesized benzimidazoles (0.01 mmol) were treated with 4-acetamidobenzene-1-sulfonyl chloride in the presence of sodium hydroxide to produce the final compounds. 24…”

Section: Synthesis Of Benzimidazole Derivatives (Ca and Cb)mentioning

confidence: 99%

Benzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment

Ullah¹,

Kury²,

Althobaiti³

et al. 2022

JIR

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The study investigated the effect of newly synthesized benzimidazole derivatives against ethanol-induced neurodegeneration. According to evidence, ethanol consumption may cause a severe insult to the central nervous system (CNS), resulting in mental retardation, neuronal degeneration, and oxidative stress. Targeting neuroinflammation and oxidative stress may be a useful strategy for preventing ethanol-induced neurodegeneration. Methodology: Firstly, the newly synthesized compounds were subjected to molecular simulation and docking in order to predict ligand binding status. Later, for in vivo observations, adult male Sprague Dawley rats were used for studying behavioral and oxidative stress markers. ELIZA kits were used to analyse tumour necrosis factor-alpha (TNF-), nuclear factor-B (NF-B), interleukin (IL-18), and pyrin domain-containing protein 3 (NLRP3) expression, while Western blotting was used to measure IL-1 and Caspase-1 expression. Results: Our findings suggested that altered levels of antioxidant enzymes were associated with elevated levels of TNF-α, NF-B, IL-1, IL-18, Caspase-1, and NLRP3 in the ethanol-treated group. Furthermore, ethanol also caused memory impairment in rats, as measured by behavioural tests. Pretreatment using selected benzimidazole significantly increased the combat of the brain against ethanol-induced oxidative stress. The neuroprotective effects of benzimidazole derivatives were promoted by their free radical scavenging activity, augmentation of endogenous antioxidant proteins (GST, GSH), and amelioration of lipid peroxide (LPO) and other pro-inflammatory mediators. Molecular docking and molecular simulation studies further supported our hypothesis that the synthetic compounds Ca and Cb had an excellent binding affinity with proper bond formation with their targets (TNF-α and NLRP3). Conclusion: It is revealed that these benzimidazole derivatives can reduce ethanol-induced neuronal toxicity by regulating the expression of cytokines, antioxidant enzymes, and the inflammatory cascade.

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Section: Synthesis Of Benzimidazole Derivatives (Ca and Cb)mentioning

confidence: 99%

Benzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment

Ullah¹,

Kury²,

Althobaiti³

et al. 2022

JIR

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“…The process related to the development of reduction methodologies involving the reduction of nitro compounds to medicinally important amide formation is always in demand. − Amide derivatives are known for various applications in agro- and pharmacy-related industries for making various surfactants, pesticides, polymers, dye precursors, and medicines. , For instance, acetanilide ( N -phenylacetamide) is used to produce 4-acetamidobenzene sulfonyl chloride (used for manufacturing sulfa drugs), paracetamol, and many more medicinally important drugs. However, their synthetic methodologies require two-step reduction of nitrobenzene to aniline, − followed by acetylation − for its preparation, which makes the reduction of nitro derivatives a multistep-complicated task.…”

Section: Introductionmentioning

confidence: 99%

Waste-Derived Iron Nanoparticles for Solvent-Free Single-Step Reductive Acetylation of Nitroarenes

Kaushik,

Sharma,

Twinkle

et al. 2023

ACS Sustainable Chem. Eng.

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A simple and single-step synthetic protocol is reported here for synthesizing medicinally important amide compounds such as acetanilide (N-phenylacetamide) and its derivatives (including paracetamol and phenacetin). Compared to the existing reports used for a single-step amidation that requires multiple reagents, herein, waste-derived iron nanoparticles (FeO x -NPs) isolated from the "free-of-cost available iron dust/powder" were used for the same single-step amidation reaction without using any external reagents and high pressure, resulting in the costeffective viable reported procedure. The Soxhlet-purified iron dust is subjected to high-temperature heating at ∼800 °C in a muffle furnace to achieve its heterogeneously active form (Fe 3 O 4 -type moieties on its surface). The as-prepared catalyst (FeO x -NPs) has been used to synthesize 17 acetanilide derivatives including two essential antipyretic drugs, paracetamol and phenacetin, on a gram scale, and one industrially important dye/pigment precursor (2-nitroacetanilide). Based on the X-ray photoelectron spectroscopy and vibrating sample magnetometry results, a possible mechanism has been proposed. The sustainability associated with the whole process is the direct amide formation using a magnetically separable waste-derived metal catalyst in solvent-free conditions, which provides a possible way to utilize large-scale industrial waste, thus directly reducing some environmental stress.

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Optimization of pencil graphite electrodes through green-synthesized iron nanomaterials for enhanced biofuel cell performance

Keerthi,

Vani,

Tharun

et al. 2024

Ionics

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Untitled

Cited by 3 publications

References 7 publications

Benzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment

Benzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment

Waste-Derived Iron Nanoparticles for Solvent-Free Single-Step Reductive Acetylation of Nitroarenes

Optimization of pencil graphite electrodes through green-synthesized iron nanomaterials for enhanced biofuel cell performance

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