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Lisgarten, David R.; Palmer, Rex A.

doi:10.1023/a:1022416309763

Cited by 2 publications

(3 citation statements)

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“…All the rings of the steroid skeleton are trans connected. The corresponding bond lengths and angles in (I) and (II) are almost equivalent and are comparable to those found in similar ring-A-modi®ed steroids (Lisgarten & Palmer, 1998;Lisgarten et al, 2003).…”

Section: Commentsupporting

confidence: 79%

“…9 2 = 270 (2) for the atom sequence C8ÐC9ÐC11ÐC12Ð C13ÐC14]. Similar conformations have been reported in related structures (Lisgarten & Palmer, 1998;Lisgarten et al, 2003). Five-membered ring D of the steroid skeleton has a 13-envelope conformation.…”

Section: Figurementioning

confidence: 54%

“…The presence of either an acetoxy or a hydroxy substituent on atom C17 does not affect the conformation of ring D in (I) and (II). In related structures (Lisgarten & Palmer, 1998;Lisgarten et al, 2003), steroidal ring D also has a half-chair conformation, even when atom C17 is disubstituted (17-hydroxy and 17-methyl).…”

Section: Figurementioning

confidence: 99%

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Two azasteroidal [3,2-c]pyrazole derivatives: 2′-(p-fluorophenyl)-4-azapyrazolo[4′,3′:2,3]-5α-androstan-17β-yl acetate and 2′-(p-fluorophenyl)-4-azapyrazolo[4′,3′:2,3]-5α-androstan-17β-ol

et al. 2003

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In both the title aza-steroids, 2'-(p-fluorophenyl)-4-azapyrazolo[4',3':2,3]-5alpha-androstan-17beta-yl acetate, C(27)H(34)FN(3)O(2), (I), and 2'-(p-fluorophenyl)-4-azapyrazolo[4',3':2,3]-5alpha-androstan-17beta-ol, C(25)H(32)FN(3)O, (II), the tetrahydropyridine ring adopts a half-chair conformation and is considerably strained as a consequence of the presence of the fused planar pyrazole ring. In both compounds, both cyclohexane rings have chair conformations, while the cyclopentane ring has an envelope conformation. All the rings of the steroid nucleus are trans fused. In (I), intermolecular N-H.O, C-H.F, C-H.O and C-H.N interactions are observed in the solid state, while intermolecular N-H.O and O-H.N hydrogen bonds are observed in (II).

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Section: Commentsupporting

confidence: 79%

Section: Figurementioning

confidence: 54%