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Iezhitsa, Igor Nikolayevich; Спасов, А. А.; Бугаева, Л. И.; Morozov, Igor

doi:10.1023/a:1016206306875

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…Spontaneous motor activity was increased after single treatment of bromantane in doses of 30-300 mg/kg, was not changed after treatment in doses of 600 mg/kg, but was inhibited after treatment in doses above 600 mg/kg. The drug reduced the pain sensitivity threshold in doses of 300-600 mg/kg, and elevated it, along with tactile sensitivity and reaction to knock, in doses above 600 mg/kg (Iezhitsa et al ., 2002).…”

Section: Other Actoprotectorsmentioning

confidence: 99%

The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance

Oliynyk¹,

Oh²

2012

Biomolecules and Therapeutics

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Actoprotectors are preparations that enhance body stability against physical loads without increasing oxygen consumption or heat production. Or, in short, actoprotectors are synthetic adaptogens with a significant capacity to improve physical performance. This paper explores the history of actoprotectors’development, their pharmacological properties, mechanism of action, and practical application to the improvement of mental and physical performance. A brief summary of the clinico-pharmacological characteristics of the main representatives of this class (bemitil and bromantane) is provided. Some other synthesized compounds, and even natural ones such as ginseng, also are regarded as potential actoprotectors, and these are treated herein as well. Actoprotectors, owing to their wide-ranging pharmacological activities, high efficiency and safety, can be applied under either normal or extreme conditions.

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Section: Other Actoprotectorsmentioning

confidence: 99%

The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance

Oliynyk¹,

Oh²

2012

Biomolecules and Therapeutics

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“…Ladasten was synthesized in 96% yield by the Leuckart reaction [16], and its stimulantlike psychotropic activity was noted. The effect of different doses of ladasten on the behavior and fertility of rats was studied in [17][18][19][20][21][22]. Ladasten was also found to stimulate expression of genes responsible for biosynthesis of dopamine in different brain areas in rats [23].…”

mentioning

confidence: 99%

Palladium-catalyzed amination of isomeric dihalobenzenes with 1- and 2-aminoadamantanes

et al. 2010

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Palladium-catalyzed amination of isomeric bromochloro-and dibromobenzenes with 1-and 2-aminoadamantanes was studied. The best yields of the corresponding monoamination products were obtained in the reactions of 2-aminoadamantane with bromochlorobenzenes. The arylation of 1-aminoadamantane was successful in the presence of donor phosphine ligand. The amination of o-and m-dibromobenzenes was strongly complicated by formation of diamination products. Conditions ensuring predominant formation of the latter were found. The arylation of 2-aminoadamantane was accompanied by oxidation of the initial amine and reduction of aryl halide.Adamantane is one of the simplest cage-like hydrocarbons, which attracts researchers' attention over a period of more than 50 years. Up to now, thousands compounds containing an adamantane fragment have been synthesized and studied, and many of them have found applications in various fields of practice, primarily as physiologically active substances. Aminoadamantanes and their derivatives are especially interesting as potential medicines; for example, adamantan-1-amine hydrochloride (amantadine) turned out to be effective in the treatment of Parkinson's disease [1,2] and was also used in the treatment of hepatitis C [3]. 1-(1-Adamantyl)ethanamine (rimantadine) [4] is widely used as antiviral agent, memantine (derivative with two amino groups) [5] is an N-methyl D-aspartate receptor antagonist; many other drugs have more complex structures and often contain aromatic fragments; examples are chlodantane (immunostimulant) [6], ladasten (neurostimulator) [7], etc. Most publications deal with adamantan-1-and -2-amine derivatives possessing an amide group; many hundreds of such compounds have already been reported. In the recent years, successful biological tests have been performed with various N-aryl-and N-hetarylaminoadamantanes, including those containing halogen atoms (fluorine, chlorine, bromine) in the aromatic substituent. Therefore, we set ourselves the task of developing a convenient procedure for the synthesis of a new family of N-haloaryl-substituted adamantanamines with a view to subsequently test them for biological activity.There are hundreds publications on the synthesis and applications of adamantan-1-amine; however, published data on the synthesis of its N-aryl derivatives are very scanty. Olifirov et al. [8] synthesized N-phenyladamantan-1-amine in 51% yield from adamantan-1-ol and aniline in the presence of aniline hydrochloride or aluminum anilide hydrochloride. In the early publication by Kogay and Sokolenko [9], the use of 1,3-dehydroadamantane was described: this compound reacted with aniline in the presence of aniline hydrochloride to produce a mixture of aniline alkylation products at the nitrogen atom and at the para-position at a ratio of 4 : 1. N-(1-Adamantyl)aniline was isolated in 55% yield. Stepanov and Stolyarov [10] synthesized N-(1-adamantyl)aniline by alkylation of aniline with 1-bromoadamantane. The reaction occurred under severe conditions and involved the nit...

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An in vitro study of low-frequency ultrasound transmission through a musculoskeletal fragment of the thoracic cage

2006

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Multifunctional capacity of ultrasonic technology and effects of ultrasound (US) on biological objects (cells, tissues, and organs) are widely used for diagnosis, therapy, and surgery of various diseases. Safety of US applications to medicine is an important factor.The effects of low intensity (<0.5 W/cm 2 ) low fre quency (50 300 kHz) US on isolated functionally active rat heart were considered in [1 3]. It was found that US induced changes in the contractile activity of myocardi um and arrhythmogenic effects, the extent of the effects being dependent on the US intensity and frequency. Similar effects of US of higher frequency were reported in earlier works [4,5]. A conclusion on possible therapeutic effect of US in cardiology was drawn in [1,3]. The car dioprotective effect of US in myocardium ischemia (sim ilar to ischemic preconditioning) was suggested in [8].However, in contrast to laboratory experiments with isolated heart, actual medical practice raises the problem of US transmission from the ultrasonic generator to the heart. US transmission through the thoracic cage wall is accompanied by its attenuation. The problem of the US effect on thoracic cage organs (ribs, intercostal tissues) is very important from the practical viewpoint. The effects of noninvasive therapeutic passage of US through the heart require quantitative experimental evaluation.The concept of US effect on biological tissues has been put forward in medical diagnosis (echocardiogra phy). The physico geometrical conditions of US use in diagnosis and therapy differ from one another. This is due to different US frequency ranges inherent in these tech nologies. This difference brings about different dimen sions of US generators used for diagnosis and therapy and different structural scales (intercostal distance) in the tho racic cage. Brief explanation is given below. The main goal of echocardiography is to obtain sufficient image resolu tion. At a first approximation, the US image resolution is determined by the length of the US half wave or US fre quency. The higher is US frequency, the larger is the atten uation decrement in biological tissue. Therefore, the depth of penetration of high frequency US is smaller. Given the compromise conditions, many US apparatuses and modes of echocardiography employ US frequencies within the range 1.5 7.5 MHz. This frequency range cor responds to the wavelength range 0.2 1 mm. To form the US beam, the characteristic aperture size of the generator should be at least one order of magnitude larger than the radiation wavelength. Thus, generators with aperture size 1 2 cm can be used for echocardiography. Such generators during a procedure can be positioned at the intercostal space, avoiding thereby the screening effect of ribs (Fig. 1a). In this case, the US passage through the thoracic cage during echocardiography is reduced to US passage through intercostal tissues [6,7]. The absence of acoustic barriers in the intercostal space makes the US beam pass ing through the intercostal windows uniform (Fig. 1a).Di...

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Untitled

Cited by 4 publications

References 2 publications

The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance

The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance

Palladium-catalyzed amination of isomeric dihalobenzenes with 1- and 2-aminoadamantanes

An in vitro study of low-frequency ultrasound transmission through a musculoskeletal fragment of the thoracic cage

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