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Syntheses and some features of five new cyclohexane-1,3-dicarboxylates with multiple stereogenic centers

“…The significant positive slopes of these correlations suggest a surprisingly strong electronic effect of the para-X group, the 1 H chemical shifts of OAH proton being more sensitive (r I = 1.42d OAH À 6.49) than NAH (r I = 1.09d NAH À 9.41) one. The obtained correlations can be used to predict and tune some properties of cyclohexanes of this type such as acidity, coordination ability [36], biological activity [5,20].…”

“…The methods of further modification of the thus prepared cyclohexanones with mono-or polyfunctional nucleophiles are also well studied [20][21][22][23][24][25][26][27][28]. For instance, it was found that reactions of hydroxylamine [9], hydrazine [23,24], ethylenediamine [27], ethanolamine [8,26,27], ethylene glycol [4], substituted aromatic amines [20,21,25], tosylhydrazide [22] and benzidine [28] with diethyl-4-hydroxy-4-methyl-6-oxo-2-phenylcyclohexane-1,3-dicarboxylate give isoxazole, imidazole and 1,3-dioxolane rings, Schiff base condensation products, etc. Moreover, in some cases the cyclization processes depend on temperature, i.e.…”

Synthesis and structure of (thio)semicarbazonocyclohexanedicarboxylates. Crystalline and molecular structure of diethyl 4-hydroxy-4-methyl-2-phenyl-6-thiosemicarbazonocyclohexane-1,3-dicarboxylate

“…Their reactions with nitrogen-centered nucleophiles have been well documented; depending on the nucleophile structure, these reactions lead to the formation of enamines, oximes, fused heterocycles, and heterocyclic spiro compounds whose structure was determined by spectral methods and X-ray analysis [4][5][6][7].…”