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Se, Zhuĭkova; Vi, Sergeev; Ge, Samonina; Nf, Myasoedov

doi:10.1023/a:1020285909696

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Previous studies showed that a NO donor Sydnopharm has antiulcer activity [6]. Combined treatment with L-arginine and ibuprofen significantly reduces the adverse effect of NSAID on GM [10].…”

Section: Resultsmentioning

confidence: 97%

Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs

et al. 2009

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We studied the effect of dalargin and its analogue [Dala]2-leu-enkephalin on the gastric mucosa in indomethacin-receiving animals. Indomethacin treatment was followed by severe injury to the gastric mucosa, decrease in proliferative activity of the epithelium, and stimulation of free-radical processes in gastric tissues. Dalargin significantly decreased the area of erosive and ulcerative lesions, had a normalizing effect on proliferation of epithelial cells, and reduced the degree of oxidative stress. Administration of [Dala]2-leu-enkephalin did not improve the state of the gastric mucosa.

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Section: Resultsmentioning

confidence: 97%

Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs

et al. 2009

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“…Realization of these properties at the tissue and organ levels seemed to prevent the disorders unfolding under the effects of mast cell mediators. The protective effect of PGP not mediated through mast cell stabilization could include peptide regulation of the vascular tone [1], endothelium permeability maintenance, maintenance of adequate bloodfl ow [2], and improvement of cell and tissue resistance to oxidative stress [5].…”

Section: Resultsmentioning

confidence: 99%

Effects of Prolyl-Glycyl-Proline (PGP) Peptide on Disorders in Rat Mesenteric Lymphatic Vessel Function Induced by Injection of Substance 48/80

et al. 2012

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“…A single intraperitoneal injection of the drug at a dose of 100 μg/kg reduced the mortality rate of animals, hyperfermentation, the activation of lipid peroxidation, and vascular permeability, and improved microcirculation and accelerated the healing of the zones of destruction of the pancreas [209]. The study of the effects of Semax on various models of ulceration showed a marked antiulcer effect of the drug [210][211][212].…”

Section: Discussionmentioning

confidence: 99%

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Kolomin¹,

Шадрина²,

Slominsky³

et al. 2013

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Natural regulatory peptides are biologically active compounds that are produced by various cells and provide a link among the main regulatory systems of the body. The field of research into the biologic activity of endogenous regulatory peptides is extremely vast. These peptides affect the cardiovascular, immune, reproductive, endocrine, digestive, and other systems, alter energy metabolism, and are especially effective in the regulation of the central nervous system. Despite of the wide range of preventive and therapeutic effects of natural regulatory peptides and proteins, their application in clinical practice is difficult. This is primarily because of their extreme instability, as they are rapidly degraded by proteases of the gastrointestinal tract, blood, cerebrospinal fluid, and other biologic media. Compounds with higher stability (i.e., a considerably longer half-life compared with that of natural molecules) and the ability to provide a directional effect on the various body systems were obtained from modifications of endogenous regulatory peptides. Synthetic analogs of regulatory peptides, as a rule, contain only natural amino acids in their composition, and their biodegradation does not lead to the formation of toxic products; thus, they have fewer side effects. This review focuses on the consideration of two synthetic regulatory peptides, Semax and Selank, which were the bases for the creation of new drugs that are used effectively in the treatment of various diseases of the nervous system. The synthetic analog of an adrenocorticotropic hormone 4-10 fragment (ACTH 4-10) Semax is a powerful neuroprotective agent that is particularly effective as a therapy for stroke. Selank was synthesized on the basis of the natural immunomodulator tuftsin. Selank is a powerful anxiolytic that is used as a therapy for generalized anxiety disorder and neurasthenia without sedative and muscle-relaxant effects. This review presents the results of research aimed at studying the influence of these peptides on the transcriptome of brain cells. The problems of drugs developed based on the clinical activities of Semax and Selank are discussed separately.

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Cited by 7 publications

References 5 publications

Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs

Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs

Effects of Prolyl-Glycyl-Proline (PGP) Peptide on Disorders in Rat Mesenteric Lymphatic Vessel Function Induced by Injection of Substance 48/80

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

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