2002
DOI: 10.1007/s00726-002-0208-9
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Abstract: Sulfate and taurine are major end products of sulfur-containing amino acid metabolism in mammals including humans, and they are excreted in urine. Average excretions micromol/mg of creatinine) in the morning urine of 58 female college students were: total (free plus ester) sulfate (a). 12.53 +/- 3.85; free sulfate, 11.57 +/- 3.69; taurine, 0.78 +/- 0.53. Ratio of total sulfate and taurine was 10 : 0.6. Regression lines obtained by plotting total sulfate, free sulfate, or total sulfate plus taurine against urea… Show more

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Cited by 13 publications
(3 citation statements)
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“…In particular, meat, eggs, and many types of cheese are rich in sulfur‐containing amino acids (cysteine, homocysteine, and methionine) (Adeva & Souto, 2011 ). These amino acids are catabolized to sulfate (Nakamura et al., 2002 ; Rehman et al., 2020 ) thereby increasing DAL. Sulfate excretion is inversely correlated with urinary pH (Adeva & Souto, 2011 ; Cosgrove & Johnston, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
“…In particular, meat, eggs, and many types of cheese are rich in sulfur‐containing amino acids (cysteine, homocysteine, and methionine) (Adeva & Souto, 2011 ). These amino acids are catabolized to sulfate (Nakamura et al., 2002 ; Rehman et al., 2020 ) thereby increasing DAL. Sulfate excretion is inversely correlated with urinary pH (Adeva & Souto, 2011 ; Cosgrove & Johnston, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
“…It has been suspected for more than 20 years that a defect exists in the hepatic biosynthesis of taurine in human patients with advanced CKD, both in pre-dialysis patients [ 11 ] and in end-stage patients receiving dialysis [ 10 , 11 ]. The steady-state rate of appearance of taurine in the urine in the absence of dietary taurine has previously been used as a measure of the endogenous rate of taurine biosynthesis [ 31 ]. The decline in taurine excretion rate in Table 3 in the present study is therefore consistent with the impaired taurine biosynthesis arising from CSAD insufficiency that was previously proposed [ 10 ].…”
Section: Discussionmentioning
confidence: 99%
“…The decline in taurine excretion rate in Table 3 in the present study is therefore consistent with the impaired taurine biosynthesis arising from CSAD insufficiency that was previously proposed [ 10 ]. In liver, CSAD is the enzyme that partitions the sulphur amino acid flux between the pathway to taurine and the alternative pathway to sulphurous and sulphuric acid (which can be assessed by measuring sulphate SO 4 2− excretion [ 31 ]). If the previously proposed insufficiency of CSAD in CKD [ 10 ] is occurring here, the ratio of taurine generation to SO 4 2− generation would be expected to decrease.…”
Section: Discussionmentioning
confidence: 99%