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Abstract

ABSTRACT:This study aims to compare the Parkinsonism behavior induced by two drugs: Tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride hydrate and MPTP (1-methyl, 4-phenyl 1,2,3,6 tetrahydropyrolidine) using a Force Plate Actimeter (FPA). 25 C57BL/6 black mice were equally divided into two groups for 5mg/kg tacrine and 30mg/kg MPTP experiment. Both groups contained sham, 5mg/kg tacrine or 30mg/kg MPTP group and sinemet group (oral administration of 10mg/kg sinemet (levodopa:carbidopa in 4:1) prior to intraperitoneal injection of 5mg/kg tacrine or 30mg/kg MPTP). Mice were immediately kept inside FPA to record their behavior. Distance travelled, bout of low mobility (BLM) and power spectra of parkinsonian symptoms shown by both drugs were computed. Both neurotoxins reduced the motor abilities of mice in comparison with sham.