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Abstract

The extracellular matrix (ECM) is the backbone in controlling cell behavior in the living organisms during the process of wound healing. The design of a suitable biomimetic nanofibrous scaffold which mimics the properties of natural ECM is a need of present time. In order to create a novel and unique wound dressing material, composite nanoscaled eudragit scaffolds loaded with gentamicin were prepared using the process of electrospinning. The nanofibers were characterized for size, size distribution, surface morphology and surface chemical structures using the Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). In-vitro release of gentamicin was also investigated. In vitro drug release tests confirmed that the nanofibers had pH-dependent drug release profiles. These properties indicate that the drug loaded eudragit nanofibrous scaffold has the potential to be used as a candidate in wound healing treatments.