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Abstract

Twelve patients with refractory rheumatoid arthritis were treated with total lymphoid irradiation (TLL) to a total cumulative dose of 3,000 rads. Post-TLI morbidity/mortality included 8 patients with xerostomia, 4 with weight loss of >10 kg, 3 with loss of 4 or more teeth, 3 with herpes zoster, 4 with bacterial infection that was fatal in 2, 3 with hypothyroidism, 1 with cutaneous vasculitis, and death from myocardial infarction in 1 patient and cardiorespiratory arrest in another. Ten of the patients were reevaluated 15-40 months (mean f SE, 30 f 2) after completion of TLI, and significant improvement was noted in several dis- ease parameters including number of swollen joints, duration of morning stiffness, and SO-foot walkidg time. _- Blood lymphopenia and a decrease in helper T cells (T4)were also noted. These data suggest that changes in immunoregulation induced by TLI can produce longlasting alterations in rheumatoid arthritis, although adverse effects may limit its efficacy.