The multitude of applications that Ultra-Wideband (UWB) technology can serve, from highspeed Wireless Personal Area Networks to Wireless Sensor Networks with precision Geolocation abilities, has attracted intense research interest in the implementation of UWB systems. The unusually wide range of frequencies assigned to UWB, from , allows UWB systems employing low order modulation schemes to enjoy high throughput at low power consumption. According to the foregoing assignment, however, UWB shares the spectrum with existing wireless networking technologies, and, thus, UWB emissions must be limited to a power spectral density below the threshold of , satisfying very stringent emission masks and introducing great challenges in the design of low power and small area transmitters.The subject of this thesis is the design of low power, fully integrated, CMOS UWB transmitters (TXs), with high spectral flexibility, high speed and high modulation quality. Due to the low power requirements, this work focused on the Impulse Radio technology, while the high spectral flexibility was partially addressed by a Multi-Band architecture, based on Up-Conversion. The resulting Multi-Band Impulse-Radio (MB-IR) TX architecture employs Gaussian baseband pulse shaping and Direct Sequence BPSK modulation.The key contributions of this thesis are a CMOS Gaussian Pulse Generator and a BSPK modulation topology, which jointly constitute a high performance analog baseband unit, and lead to a reconfigurable, low power, low EVM, Gigabit MB-IR UWB transmitter RFIC, which is FCC/ECC mask compliant without the need for any off-chip components.The novel Pulse Generator (PG) is based on non-linear shaping, so as to facilitate the configurability of the output pulse duration, and exploits the voltage transfer characteristic of a Resistive Loaded Asymmetrical CMOS Inverter (RLACI), which results in spectral sidelobes typically better than . The PG incorporates low voltage circuits of digital nature, while the MOSFET devices that undertake the pulse shaping avoid exclusive operation in weak inversion, in contrast to previous implementations. Consequently, the proposed CMOS PG is able to support higher throughput, as well as higher output amplitude, which relaxes considerably the design of the RF front end.