This paper describes a novel low-latency 4K 60 fps HEVC (high efficiency video coding)/H.265 multi-channel encoding system with content-aware bitrate control for live streaming. Adaptive bitrate (ABR) streaming techniques, such as MPEG-DASH (dynamic adaptive streaming over HTTP) and HLS (HTTP live streaming), spread widely on Internet video streaming. Live content has increased with the expansion of streaming services, which has led to demands for traffic reduction and low latency. To reduce network traffic, we propose content-aware dynamic and seamless bitrate control that supports multi-channel real-time encoding for ABR, including 4K 60 fps video. Our method further supports chunked packaging transfer to provide low-latency streaming. We adopt a hybrid architecture consisting of hardware and software processing. The system consists of multiple 4K HEVC encoder LSIs that each LSI can encode 4K 60 fps or up to high-definition (HD) ×4 videos efficiently with the proposed bitrate control method. The software takes the packaging process according to the various streaming protocol. Experimental results indicate that our method reduces encoding bitrates obtained with constant bitrate encoding by as much as 56.7%, and the streaming latency over MPEG-DASH is 1.77 seconds.