Carbon-nanotube (CNT)-based sensors offer the potential to detect single-molecule events and picomolar analyte concentrations. An important step toward applications of such nanosensors is their integration in large arrays. The availability of large arrays would enable multiplexed and parallel sensing, and the simultaneously obtained sensor signals would facilitate statistical analysis. A reliable method to fabricate an array of 1024 CNT-based sensors on a fully processed complementary-metal-oxide-semiconductor microsystem is presented. A high-yield process for the deposition of CNTs from a suspension by means of liquid-coupled floating-electrode dielectrophoresis (DEP), which yielded 80% of the sensor devices featuring between one and five CNTs, is developed. The mechanism of floating-electrode DEP on full arrays and individual devices to understand its self-limiting behavior is studied. The resistance distributions across the array of CNT devices with respect to different DEP parameters are characterized. The CNT devices are then operated as liquid-gated CNT field-effect-transistors (LG-CNTFET) in liquid environment. Current dependency to the gate voltage of up to two orders of magnitude is recorded. Finally, the sensors are validated by studying the pH dependency of the LG-CNTFET conductance and it is demonstrated that 73% of the CNT sensors of a given microsystem show a resistance decrease upon increasing the pH value.The potential of carbon nanotubes (CNTs) as electronic sensors in liquid environments has been extensively demonstrated.
Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts electronic environment and the nanotube's high surface/volume ratio render them particularly suited for sensing applications in liquid phases. Furthermore, through functionalization of the CNTs, a specificity for numerous analytes can be achieved. [1][2][3][4][5] Highly sensitive CNT nanosensors have been demonstrated in liquid-gate CNT field-effecttransistor (LG-CNTFET) configurations, where the carrier density of the CNT gate was controlled via a potential applied to the surrounding electrolyte.[6] By using LG-CNTFET sensors consisting of only a single or a small number of individual CNTs as sensing material, only few molecules are required to generate detectable signals. In the case of DNA hybridization, even the detection of a single molecule is possible. [7,8] Despite their application potential in point-of-care diagnosis and label-free sensing, the widespread use of CNT nanosensor technologies is still hampered by technological hurdles. First of all, a route to fabricating large numbers of devices with reproducible characteristics has to be developed. Additionally, the high sensitivity of CNT sensors entails the presence of baseline fluctuations due to unspecific and random adsorption events, which are likely to create detection errors.[9] Finally, the limited adsorption area of single-CNT nanosensors leads to slow response times for low concentrations.[10]A possibility to overcome some o...